[HTML][HTML] KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation
The first step of RAF activation involves binding to active RAS, resulting in the recruitment of
RAF to the plasma membrane. To understand the molecular details of RAS-RAF interaction, …
RAF to the plasma membrane. To understand the molecular details of RAS-RAF interaction, …
Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ
S Dharmaiah, L Bindu, TH Tran… - Proceedings of the …, 2016 - National Acad Sciences
Farnesylation and carboxymethylation of KRAS4b (Kirsten rat sarcoma isoform 4b) are
essential for its interaction with the plasma membrane where KRAS-mediated signaling events …
essential for its interaction with the plasma membrane where KRAS-mediated signaling events …
[PDF][PDF] Inhibition of Ras/Raf/MEK/ERK pathway signaling by a stress-induced phospho-regulatory circuit
DA Ritt, MT Abreu-Blanco, L Bindu, DE Durrant… - Molecular cell, 2016 - cell.com
Ras pathway signaling plays a critical role in cell growth control and is often upregulated in
human cancer. The Raf kinases selectively interact with GTP-bound Ras and are important …
human cancer. The Raf kinases selectively interact with GTP-bound Ras and are important …
Comparative analysis of 10 small molecules binding to carbonic anhydrase II by different investigators using Biacore technology
…, R Wilton, H Qiu, M Steukers, S Wang, L Bindu… - Analytical …, 2006 - Elsevier
In this benchmark study, 26 investigators were asked to characterize the kinetics and affinities
of 10 sulfonamide inhibitors binding to the enzyme carbonic anhydrase II using Biacore …
of 10 sulfonamide inhibitors binding to the enzyme carbonic anhydrase II using Biacore …
Synthesis and biological evaluation of indenoisoquinolines that inhibit both tyrosyl-DNA phosphodiesterase I (Tdp1) and topoisomerase I (Top1)
…, A Renaud, AG Stephen, LK Bindu… - Journal of medicinal …, 2013 - ACS Publications
Tyrosyl-DNA phosphodiesterase I (Tdp1) plays a key role in the repair of damaged DNA
resulting from the topoisomerase I (Top1) inhibitor camptothecin and a variety of other DNA-…
resulting from the topoisomerase I (Top1) inhibitor camptothecin and a variety of other DNA-…
[HTML][HTML] Farnesylated and methylated KRAS4b: high yield production of protein suitable for biophysical studies of prenylated protein-lipid interactions
…, D Esposito, M Abreu Blanco, P Alexander, L Bindu… - Scientific reports, 2015 - nature.com
Prenylated proteins play key roles in several human diseases including cancer, atherosclerosis
and Alzheimer’s disease. KRAS4b, which is frequently mutated in pancreatic, colon and …
and Alzheimer’s disease. KRAS4b, which is frequently mutated in pancreatic, colon and …
[PDF][PDF] KRAS prenylation is required for bivalent binding with calmodulin in a nucleotide-independent manner
…, R Ghirlando, T Taylor, S Messing, TH Tran, L Bindu… - Biophysical journal, 2019 - cell.com
Deregulation of KRAS4b signaling pathway has been implicated in 30% of all cancers.
Membrane localization of KRAS4b is an essential step for the initiation of the downstream …
Membrane localization of KRAS4b is an essential step for the initiation of the downstream …
[HTML][HTML] Quantitative biophysical analysis defines key components modulating recruitment of the GTPase KRAS to the plasma membrane
B Lakshman, S Messing, EM Schmid… - Journal of Biological …, 2019 - ASBMB
The gene encoding the GTPase KRAS is frequently mutated in pancreatic, lung, and colorectal
cancers. The KRAS fraction in the plasma membrane (PM) correlates with activation of …
cancers. The KRAS fraction in the plasma membrane (PM) correlates with activation of …
Membrane curvature sensing of the lipid-anchored K-Ras small GTPase
…, H Mu, F Jean-Francois, B Lakshman… - Life Science …, 2019 - life-science-alliance.org
Plasma membrane (PM) curvature defines cell shape and intracellular organelle morphologies
and is a fundamental cell property. Growth/proliferation is more stimulated in flatter cells …
and is a fundamental cell property. Growth/proliferation is more stimulated in flatter cells …
The bacterial Ras/Rap1 site-specific endopeptidase RRSP cleaves Ras through an atypical mechanism to disrupt Ras-ERK signaling
…, A Herrera, PJ Woida, MB Kieffer, L Bindu… - Science …, 2018 - science.org
The Ras–extracellular signal–regulated kinase pathway is critical for controlling cell
proliferation, and its aberrant activation drives the growth of various cancers. Because many …
proliferation, and its aberrant activation drives the growth of various cancers. Because many …