Neuropilin-1 (Npn-1) is a receptor that binds multiple ligands from structurally distinct
families, including secreted semaphorins (Sema) and vascular endothelial growth factors (VEGF). …

Lampreys are representatives of an ancient vertebrate lineage that diverged from our own∼
500 million years ago. By virtue of this deeply shared ancestry, the sea lamprey (P. marinus) …

▪ Abstract The neurons of the cochlear ganglion transmit acoustic information between the
inner ear and the brain. These placodally derived neurons must produce a topographically …

We investigated whether co‐expression of Neurog1 and Atoh1 in common neurosensory
precursors could explain the loss of hair cells in Neurog1 null mice. Analysis of terminal mitosis…

Sox2 is a high-mobility transcription factor that is one of the earliest markers of developing
inner ear prosensory domains. In humans, mutations in SOX2 cause sensorineural hearing …

A key factor in the genetically programmed development of the nervous system is the death
of massive numbers of neurons. Therefore, genetic mechanisms governing cell survival are …

The proprioceptive system provides continuous positional information on the limbs and body
to the thalamus, cortex, pontine nucleus, and cerebellum. We showed previously that the …

The proneuronal gene neurogenin 1 (ngn1) is essential for development of the inner-ear
sensory neurons that are completely absent in ngn1 null mutants. Neither afferent, efferent, nor …

Previous work suggested qualitatively different effects of neurotrophin 3 (NT-3) in cochlear
innervation patterning in different null mutants. We now show that allNT-3 null mutants have a …

The developing vertebrate mesencephalon shows a rostrocaudal gradient in the expression
of a number of molecular markers and in the cytoarchitectonic differentiation of the tectum, …