Calcium ions as second messengers control many biological processes, at least in part, via
interaction with a large number of Ca 2+ -binding proteins. One class of these proteins …

Development of chemotherapeutic treatment modalities resulted in a dramatic increase in
the survival of children with many types of cancer. Still, in case of some pediatric cancer …

Chromosomal rearrangements of the human MLL/KMT2A gene are associated with infant,
pediatric, adult and therapy-induced acute leukemias. Here we present the data obtained …

Rhabdomyosarcomas (RMSs) are the most common soft tissue sarcomas in children/adolescents
less than 18 years of age with an annual incidence of 1–2/million. Inter/intra-tumour …

The prognostic value of MRD in large series of childhood T-ALL has not yet been established.
Trial AIEOP-BFM-ALL 2000 introduced standardized quantitative assessment of MRD for …

In vivo resistance to first-line chemotherapy, including to glucocorticoids, is a strong predictor
of poor outcome in children with acute lymphoblastic leukemia (ALL). Modulation of cell …

During sarcomere contraction skeletal and cardiac muscle cells consume large amounts of
energy. To satisfy this demand, metabolic enzymes are associated with distinct regions of the …

Rhabdomyosarcoma is a pediatric tumor type, which is classified based on histological
criteria into two major subgroups, namely embryonal rhabdomyosarcoma and alveolar …

The expression of a number of human paired box-containing (PAX) genes has been correlated
with various types of tumors. Novel fusion genes encoding chimeric fusion proteins have …

Head and neck squamous cell carcinoma express high levels of the EF-hand calcium-binding
protein S100A2 in contrast to other tumorigenic tissues and cell lines where the …