[HTML][HTML] Membrane curvature modulation of protein activity determined by NMR

RM Epand, K D'Souza, B Berno, M Schlame - Biochimica et Biophysica …, 2015 - Elsevier
In addition to specific intermolecular interactions, biological processes at membranes are
also modulated by the physical properties of the membrane. One of these properties is …

Bacterial membranes as predictors of antimicrobial potency

RM Epand, S Rotem, A Mor, B Berno… - Journal of the American …, 2008 - ACS Publications
… pneumonia and B. polymyxa, that had not been previously studied with OAKs. We predicted
B. polymyxa represents an exception to the general rule that Gram-positive bacteria have a …

The physical state of lipid substrates provides transacylation specificity for tafazzin

M Schlame, D Acehan, B Berno, Y Xu, S Valvo… - Nature chemical …, 2012 - nature.com
Cardiolipin is a mitochondrial phospholipid with a characteristic acyl chain composition that
depends on the function of tafazzin, a phospholipid-lysophospholipid transacylase, although …

Atomic force microscopy study of polypropylene surfaces treated by UV and ozone exposure: modification of morphology and adhesion force

HY Nie, MJ Walzak, B Berno, NS McIntyre - Applied Surface Science, 1999 - Elsevier
Exposing polypropylene (PP) to ozone in the presence of UV light is a simple and effective
way of modifying its surface to improve its wettability and adhesion. Atomic force microscopy (…

Loss of protein association causes cardiolipin degradation in Barth syndrome

Y Xu, CKL Phoon, B Berno, K D'Souza, E Hoedt… - Nature chemical …, 2016 - nature.com
… (b,c) 31 P-NMR spectra from mitochondrial membranes prepared from human lymphoblasts
(b) or mouse kidneys (c), solubilized with digitonin, showing the major phospholipids with …

Lipid segregation explains selective toxicity of a series of fragments derived from the human cathelicidin LL-37

RF Epand, G Wang, B Berno… - Antimicrobial agents and …, 2009 - Am Soc Microbiol
The only human cathelicidin, the 37-residue peptide LL-37, exhibits antimicrobial activity
against both gram-positive and gram-negative bacteria. We studied the ability of several …

The effect of processing on the structural characteristics of vancomycin-loaded amorphous calcium phosphate matrices

A Dion, B Berno, G Hall, MJ Filiaggi - Biomaterials, 2005 - Elsevier
Calcium polyphosphate antibiotic delivery matrices were prepared using a unique processing
technique involving the exposure of calcium polyphosphate pastes to high humidity for 0, 5…

[HTML][HTML] Membrane curvature allosterically regulates the phosphatidylinositol cycle, controlling its rate and acyl-chain composition of its lipid intermediates

…, D Lameire, P Chatha, T Kimura, B Berno… - Journal of Biological …, 2018 - ASBMB
Signaling events at membranes are often mediated by membrane lipid composition or
membrane physical properties. These membrane properties could act either by favoring the …

Plasmalogen loss caused by remodeling deficiency in mitochondria

…, M Ren, V Monteiro, Y Xu, B Berno… - Life Science …, 2019 - life-science-alliance.org
… (B) 31 P NMR spectra in the choline glycerophospholipid region of the mouse heart
phospholipids and in the ethanolamine glycerophospholipid region of the mouse brain, liver, kidney, …

Substantial decrease in plasmalogen in the heart associated with tafazzin deficiency

T Kimura, AK Kimura, M Ren, B Berno, Y Xu… - Biochemistry, 2018 - ACS Publications
Tafazzin is the mitochondrial enzyme that catalyzes transacylation between a phospholipid
and a lysophospholipid in remodeling. Mutations in tafazzin cause Barth syndrome, a …