The genome of viruses classified as picornaviruses consists of a single monocistronic positive
strand RNA. The coding capacity of these RNA viruses is rather limited, and thus, they rely …

RNA-binding proteins (RBPs) play a pivotal role in the lifespan of RNAs. The disfunction of
RBPs is frequently the cause of cell disorders which are incompatible with life. Furthermore, …

Viral RNAs contain the information needed to synthesize their own proteins, to replicate, and
to spread to susceptible cells. However, due to their reduced coding capacity RNA viruses …

The hereditary ataxias are a heterogenous group of disorders with an increasing number of
causative genes being described. Due to the clinical and genetic heterogeneity seen in …

Gemin5 in the Survival Motor Neuron (SMN) complex serves as the RNA-binding protein to
deliver small nuclear RNAs (snRNAs) to the small nuclear ribonucleoprotein Sm complex via …

Selective translation allows to orchestrate the expression of specific proteins in response to
different signals through the concerted action of cis-acting elements and RNA-binding …

In all organisms, a selected type of proteins accomplishes critical roles in cellular processes
that govern gene expression. The multifunctional protein Gemin5 cooperates in translation …

Dysfunction of RNA-binding proteins is often linked to a wide range of human disease,
particularly with neurological conditions. Gemin5 is a member of the survival of the motor neurons …

The fate of cellular RNAs is largely dependent on their structural conformation, which
determines the assembly of ribonucleoprotein (RNP) complexes. Consequently, RNA‐binding …

Regulation of protein synthesis is an essential step of gene expression. This process is under
the control of cis-acting RNA elements and trans-acting factors. Gemin5 is a multifunctional …