Plk1 regulates spindle orientation by phosphorylating NuMA in human cells

S Sana, R Keshri, A Rajeevan… - Life Science …, 2018 - life-science-alliance.org
Proper orientation of the mitotic spindle defines the correct division plane and is essential
for accurate cell division and development. In metazoans, an evolutionarily conserved …

[PDF][PDF] Innate immune sensing of influenza A viral RNA through IFI16 promotes pyroptotic cell death

S Mishra, AS Raj, A Kumar, A Rajeevan, P Kumari… - Iscience, 2022 - cell.com
Programmed cell death pathways are triggered by various stresses or stimuli, including viral
infections. The mechanism underlying the regulation of these pathways upon Influenza A …

PP2A-B55γ counteracts Cdk1 and regulates proper spindle orientation through the cortical dynein adaptor NuMA

R Keshri, A Rajeevan, S Kotak - Journal of cell science, 2020 - journals.biologists.com
Proper orientation of the mitotic spindle is critical for accurate development and morphogenesis.
In human cells, spindle orientation is regulated by the evolutionarily conserved protein …

Membrane compartmentalization of Ect2/Cyk4/Mklp1 and NuMA/dynein regulates cleavage furrow formation

S Sana, A Rajeevan, S Kotak - Journal of Cell Biology, 2022 - rupress.org
In animal cells, spindle elongation during anaphase is temporally coupled with cleavage
furrow formation. Spindle elongation during anaphase is regulated by NuMA/dynein/dynactin …

NuMA interaction with chromatin is vital for proper chromosome decondensation at the mitotic exit

A Rajeevan, R Keshri, S Kapoor… - Molecular biology of the …, 2020 - Am Soc Cell Biol
NuMA is an abundant long coiled-coil protein that plays a prominent role in spindle organization
during mitosis. In interphase, NuMA is localized to the nucleus and hypothesized to …

Membrane compartmentalization of Ect2/Cyk4/Mklp1 and NuMA/dynein/dynactin is essential for cleavage furrow formation during anaphase

S Sana, A Rajeevan, S Kotak - bioRxiv, 2022 - biorxiv.org
In animal cells, spindle elongation during anaphase is temporally coupled with cleavage
furrow formation. Spindle elongation during anaphase is regulated by NuMA/dynein/dynactin …

NuMA interaction with chromatin is vital for proper nuclear architecture in human cells

A Rajeevan, R Keshri, S Kotak - bioRxiv, 2020 - biorxiv.org
NuMA is an abundant long-coiled-coil protein that plays a prominent role in spindle organization
during mitosis. In interphase, NuMA is localized to the nucleus and hypothesized to …

Dissecting the function of NuMA in cleavage furrow formation and chromatin decondensation at the mitotic exit in animal cells

A Rajeevan - 2023 - etd.iisc.ac.in
In animal cells, the duplicated genetic material is aligned on a microtubule-based structure
known as the mitotic spindle during mitosis. At the mitotic exit, the mitotic spindle elongates, …

[HTML][HTML] Mechanisms of spindle positioning: lessons from worms and mammalian cells

S Kotak - Biomolecules, 2019 - mdpi.com
Proper positioning of the mitotic spindle is fundamental for specifying the site for cleavage
furrow, and thus regulates the appropriate sizes and accurate distribution of the cell fate …

Aneuploidy and cell cycle control in the mouse preimplantation embryo

H Brennan-Craddock - 2023 - papyrus.bib.umontreal.ca
During cell division, it is essential that chromosome segregation during mitosis, and the
partitioning of the cytoplasm at cytokinesis occur in successive timing to maintain genomic …