While the role of ATP-dependent chromatin remodeling in transcription is well established,
a link between chromatin remodeling and DNA repair has remained elusive. We have found …

Chromatin-modifying factors have essential roles in DNA processing pathways that dictate
cellular functions. The ability of chromatin modifiers, including the INO80 and SWR1 chromatin…

Somatic mutations in driver genes may ultimately lead to the development of cancer.
Understanding how somatic mutations accumulate in cancer genomes and the underlying factors …

The yeast Mec1/Tel1 kinases, ATM/ATR in mammals, coordinate the DNA damage response
by phosphorylating proteins involved in DNA repair and checkpoint pathways. Recently, …

Background Somatic mutations in healthy tissues contribute to aging, neurodegeneration,
and cancer initiation, yet they remain largely uncharacterized. Results To gain a better …

Metabolic signaling to chromatin often underlies how adaptive transcriptional responses are
controlled. While intermediary metabolites serve as co-factors for histone-modifying …

The development of many sporadic cancers is directly initiated by carcinogen exposure.
Carcinogens induce malignancies by creating DNA lesions (ie, adducts) that can result in …

During development, the formation of a mature, well-functioning heart requires transformation
of the ventricular wall from a loose trabecular network into a dense compact myocardium …

The YEATS domain, found in a number of chromatin-associated proteins, has recently been
shown to have the capacity to bind histone lysine acetylation. Here, we show that the YEATS …

Aims Non-compaction cardiomyopathy is a devastating genetic disease caused by insufficient
consolidation of ventricular wall muscle that can result in inadequate cardiac performance…