Patients with acute-on-chronic liver failure have increased numbers of regulatory immune cells expressing the receptor tyrosine kinase MERTK
C Bernsmeier, OT Pop, A Singanayagam… - Gastroenterology, 2015 - Elsevier
Background & Aims Characteristics of decompensated cirrhosis and acute-on-chronic liver
failure (ACLF) include susceptibility to infection, immuneparesis, and monocyte dysfunction. …
failure (ACLF) include susceptibility to infection, immuneparesis, and monocyte dysfunction. …
MerTK expressing hepatic macrophages promote the resolution of inflammation in acute liver failure
…, LA Possamai, A Wilhelm, E Liaskou, A Singanayagam… - Gut, 2018 - gut.bmj.com
Objective Acute liver failure (ALF) is characterised by overwhelming hepatocyte death and
liver inflammation with massive infiltration of myeloid cells in necrotic areas. The mechanisms …
liver inflammation with massive infiltration of myeloid cells in necrotic areas. The mechanisms …
CD14+ CD15− HLA-DR− myeloid-derived suppressor cells impair antimicrobial responses in patients with acute-on-chronic liver failure
…, R Brenig, FJ Lebosse, A Singanayagam… - gut, 2018 - gut.bmj.com
Objective Immune paresis in patients with acute-on-chronic liver failure (ACLF) accounts for
infection susceptibility and increased mortality. Immunosuppressive mononuclear CD14 + …
infection susceptibility and increased mortality. Immunosuppressive mononuclear CD14 + …
Balanced haemostasis with both hypo-and hyper-coagulable features in critically ill patients with acute-on-chronic-liver failure
C Fisher, VC Patel, SH Stoy, A Singanayagam… - Journal of Critical …, 2018 - Elsevier
Background Cirrhotic patients have complex haemostatic abnormalities. Current evidence
suggests stable cirrhotic (SC) patients have a “re-balanced” haemostatic state. However, …
suggests stable cirrhotic (SC) patients have a “re-balanced” haemostatic state. However, …
[HTML][HTML] Macrophages in chronic liver failure: diversity, plasticity and therapeutic targeting
A Singanayagam, E Triantafyllou - Frontiers in Immunology, 2021 - frontiersin.org
Chronic liver injury results in immune-driven progressive fibrosis, with risk of cirrhosis
development and impact on morbidity and mortality. Persistent liver cell damage and death causes …
development and impact on morbidity and mortality. Persistent liver cell damage and death causes …
[HTML][HTML] CD8+ T cells from patients with cirrhosis display a phenotype that may contribute to cirrhosis-associated immune dysfunction
F Lebossé, C Gudd, E Tunc, A Singanayagam… - …, 2019 - thelancet.com
Background Cirrhosis-associated immune dysfunction (CAID) contributes to high sepsis risk
in patients with chronic liver disease. Various innate and; to a lesser extent; adaptive …
in patients with chronic liver disease. Various innate and; to a lesser extent; adaptive …
[HTML][HTML] Lysophosphatidylcholines modulate immunoregulatory checkpoints in peripheral monocytes and are associated with mortality in people with acute liver …
Background & Aims Acute liver failure (ALF) is a life-threatening disease characterised by
high-grade inflammation and immunoparesis, which is associated with a high incidence of …
high-grade inflammation and immunoparesis, which is associated with a high incidence of …
In vitro efficacy of pro‐and anticoagulant strategies in compensated and acutely ill patients with cirrhosis
…, J Adelmeijer, S Bos, A Singanayagam… - Liver …, 2018 - Wiley Online Library
Background & Aims A simultaneous decline in pro‐ and anticoagulant drivers in patients
with liver diseases results in a “rebalanced” haemostatic system, even in acutely ill patients. …
with liver diseases results in a “rebalanced” haemostatic system, even in acutely ill patients. …
Update on acute liver failure
A Singanayagam, W Bernal - Current opinion in critical care, 2015 - journals.lww.com
Traditional dogma in ALF management is questioned: transplant thresholds for acetaminophen
overdose, steroid use in autoimmune ALF, routine antimicrobial prophylaxis, the …
overdose, steroid use in autoimmune ALF, routine antimicrobial prophylaxis, the …
[HTML][HTML] Increased expression of cytotoxic t-lymphocyte− associated protein 4 by T cells, induced by B7 in sera, reduces adaptive immunity in patients with acute liver …
…, C Bernsmeier, FS Larsen, A Singanayagam… - Gastroenterology, 2017 - Elsevier
Background & Aims Patients with acute liver failure (ALF) have defects in innate immune
responses to microbes (immune paresis) and are susceptible to sepsis. Cytotoxic T-lymphocyte…
responses to microbes (immune paresis) and are susceptible to sepsis. Cytotoxic T-lymphocyte…