Morphological and biochemical features of Borrelia burgdorferi pleomorphic forms

L Meriläinen, A Herranen, A Schwarzbach… - …, 2015 - microbiologyresearch.org
The spirochaete bacterium Borrelia burgdorferi sensu lato is the causative agent of Lyme
disease, the most common tick-borne infection in the northern hemisphere. There is a long-…

[HTML][HTML] Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss

A Herranen, K Ikäheimo, T Lankinen, E Pakarinen… - Cell death & …, 2020 - nature.com
The non-conventional neurotrophic factor mesencephalic astrocyte-derived neurotrophic factor
(MANF) is an endoplasmic reticulum (ER)-resident protein that promotes ER homeostasis…

[HTML][HTML] Transient developmental exposure to low doses of bisphenol F negatively affects neurogliogenesis and olfactory behaviour in adult mice

P Vancamp, L Butruille, A Herranen, A Boelen… - Environment …, 2023 - Elsevier
Neural stem cells in the murine subventricular zone (SVZ) reactivate during postnatal development
to generate neurons and glia throughout adulthood. We previously demonstrated that …

[HTML][HTML] Pleomorphic forms of Borrelia burgdorferi induce distinct immune responses

L Meriläinen, H Brander, A Herranen… - Microbes and …, 2016 - Elsevier
Borrelia burgdorferi is the causative agent of tick-borne Lyme disease. As a response to
environmental stress B. burgdorferi can change its morphology to a round body form. The role of …

The stress response in the non-sensory cells of the cochlea under pathological conditions—possible role in mediating noise vulnerability

A Herranen, K Ikäheimo, J Virkkala… - Journal of the Association …, 2018 - Springer
Various stressors, such as loud sounds and the effects of aging, impair the function and
viability of the cochlear sensory cells, the hair cells. Stressors trigger pathophysiological …

[HTML][HTML] 2, 4, 6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling

E Loeuillard, J Bertrand, A Herranen… - World journal of …, 2014 - ncbi.nlm.nih.gov
METHODS: Chronic colitis was induced in rats by repeated administration of increasing dose
of 2, 4, 6-trinitrobenzene sulfonic acid (TNBS, 15, 30, 45, 60, 60, 60 mg) by rectal injection …

c-Jun N-terminal phosphorylation: biomarker for cellular stress rather than cell death in the injured cochlea

T Anttonen, A Herranen, J Virkkala, A Kirjavainen… - Eneuro, 2016 - eneuro.org
Prevention of auditory hair cell death offers therapeutic potential to rescue hearing.
Pharmacological blockade of JNK/c-Jun signaling attenuates injury-induced hair cell loss, but with …

MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochlea

K Ikäheimo, A Herranen, V Iivanainen… - Life Science …, 2022 - life-science-alliance.org
Failure in the structural maintenance of the hair cell stereocilia bundle and ribbon synapse
causes hearing loss. Here, we have studied how ER stress elicits hair cell pathology, using …

Cytoskeletal stability in the auditory organ in vivo: RhoA is dispensable for wound healing but essential for hair cell development

T Anttonen, I Belevich, M Laos, A Herranen, E Jokitalo… - eneuro, 2017 - eneuro.org
Wound healing in the inner ear sensory epithelia is performed by the apical domains of
supporting cells (SCs). Junctional F-actin belts of SCs are thin during development but become …

[HTML][HTML] Trauma-induced cellular stress signalling and hair cell death in the cochlea

A Herranen - 2020 - helda.helsinki.fi
Cochlea is the peripheral receptive component of the auditory system. It contains two types
of hair cells, inner and outer hair cells (IHCs and OHCs respectively). IHCs are the major …