Morphological and biochemical features of Borrelia burgdorferi pleomorphic forms
L Meriläinen, A Herranen, A Schwarzbach… - …, 2015 - microbiologyresearch.org
The spirochaete bacterium Borrelia burgdorferi sensu lato is the causative agent of Lyme
disease, the most common tick-borne infection in the northern hemisphere. There is a long-…
disease, the most common tick-borne infection in the northern hemisphere. There is a long-…
[HTML][HTML] Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss
A Herranen, K Ikäheimo, T Lankinen, E Pakarinen… - Cell death & …, 2020 - nature.com
The non-conventional neurotrophic factor mesencephalic astrocyte-derived neurotrophic factor
(MANF) is an endoplasmic reticulum (ER)-resident protein that promotes ER homeostasis…
(MANF) is an endoplasmic reticulum (ER)-resident protein that promotes ER homeostasis…
[HTML][HTML] Transient developmental exposure to low doses of bisphenol F negatively affects neurogliogenesis and olfactory behaviour in adult mice
Neural stem cells in the murine subventricular zone (SVZ) reactivate during postnatal development
to generate neurons and glia throughout adulthood. We previously demonstrated that …
to generate neurons and glia throughout adulthood. We previously demonstrated that …
[HTML][HTML] Pleomorphic forms of Borrelia burgdorferi induce distinct immune responses
L Meriläinen, H Brander, A Herranen… - Microbes and …, 2016 - Elsevier
Borrelia burgdorferi is the causative agent of tick-borne Lyme disease. As a response to
environmental stress B. burgdorferi can change its morphology to a round body form. The role of …
environmental stress B. burgdorferi can change its morphology to a round body form. The role of …
The stress response in the non-sensory cells of the cochlea under pathological conditions—possible role in mediating noise vulnerability
A Herranen, K Ikäheimo, J Virkkala… - Journal of the Association …, 2018 - Springer
Various stressors, such as loud sounds and the effects of aging, impair the function and
viability of the cochlear sensory cells, the hair cells. Stressors trigger pathophysiological …
viability of the cochlear sensory cells, the hair cells. Stressors trigger pathophysiological …
[HTML][HTML] 2, 4, 6-trinitrobenzene sulfonic acid-induced chronic colitis with fibrosis and modulation of TGF-β1 signaling
E Loeuillard, J Bertrand, A Herranen… - World journal of …, 2014 - ncbi.nlm.nih.gov
METHODS: Chronic colitis was induced in rats by repeated administration of increasing dose
of 2, 4, 6-trinitrobenzene sulfonic acid (TNBS, 15, 30, 45, 60, 60, 60 mg) by rectal injection …
of 2, 4, 6-trinitrobenzene sulfonic acid (TNBS, 15, 30, 45, 60, 60, 60 mg) by rectal injection …
c-Jun N-terminal phosphorylation: biomarker for cellular stress rather than cell death in the injured cochlea
T Anttonen, A Herranen, J Virkkala, A Kirjavainen… - Eneuro, 2016 - eneuro.org
Prevention of auditory hair cell death offers therapeutic potential to rescue hearing.
Pharmacological blockade of JNK/c-Jun signaling attenuates injury-induced hair cell loss, but with …
Pharmacological blockade of JNK/c-Jun signaling attenuates injury-induced hair cell loss, but with …
MANF supports the inner hair cell synapse and the outer hair cell stereocilia bundle in the cochlea
K Ikäheimo, A Herranen, V Iivanainen… - Life Science …, 2022 - life-science-alliance.org
Failure in the structural maintenance of the hair cell stereocilia bundle and ribbon synapse
causes hearing loss. Here, we have studied how ER stress elicits hair cell pathology, using …
causes hearing loss. Here, we have studied how ER stress elicits hair cell pathology, using …
Cytoskeletal stability in the auditory organ in vivo: RhoA is dispensable for wound healing but essential for hair cell development
T Anttonen, I Belevich, M Laos, A Herranen, E Jokitalo… - eneuro, 2017 - eneuro.org
Wound healing in the inner ear sensory epithelia is performed by the apical domains of
supporting cells (SCs). Junctional F-actin belts of SCs are thin during development but become …
supporting cells (SCs). Junctional F-actin belts of SCs are thin during development but become …
[HTML][HTML] Trauma-induced cellular stress signalling and hair cell death in the cochlea
A Herranen - 2020 - helda.helsinki.fi
Cochlea is the peripheral receptive component of the auditory system. It contains two types
of hair cells, inner and outer hair cells (IHCs and OHCs respectively). IHCs are the major …
of hair cells, inner and outer hair cells (IHCs and OHCs respectively). IHCs are the major …