[HTML][HTML] Structure based identification and characterization of flavonoids that disrupt human papillomavirus-16 E6 function

JJ Cherry, A Rietz, A Malinkevich, Y Liu, M Xie… - PloS one, 2013 - journals.plos.org
Expression and function of the human papillomavirus (HPV) early protein 6 (E6) is necessary
for viral replication and oncogenesis in cervical cancers. HPV E6 targets the tumor …

[HTML][HTML] Endocytotic internalization as a crucial factor for the cytotoxicity of ribonucleases

F Leich, N Stohr, A Rietz, R Ulbrich-Hofmann… - Journal of Biological …, 2007 - ASBMB
The cytotoxic action of ribonucleases (RNases) requires the interaction of the enzyme with
the cellular membrane, its internalization, translocation to the cytosol, and the degradation of …

[HTML][HTML] Molecular probing of the HPV-16 E6 protein alpha helix binding groove with small molecule inhibitors

A Rietz, DP Petrov, M Bartolowits, M DeSmet… - PLoS …, 2016 - journals.plos.org
The human papillomavirus (HPV) HPV E6 protein has emerged as a central oncoprotein in
HPV-associated cancers in which sustained expression is required for tumor progression. A …

[HTML][HTML] The replicative consequences of papillomavirus E2 protein binding to the origin replication factor ORC2

M DeSmet, S Kanginakudru, A Rietz, WH Wu… - PLoS …, 2016 - journals.plos.org
The origin recognition complex (ORC) coordinates a series of events that lead to initiation of
DNA strand duplication. As a nuclear double stranded DNA plasmid, the papillomavirus (PV…

Discovery of a small molecule probe that post-translationally stabilizes the survival motor neuron protein for the treatment of spinal muscular atrophy

A Rietz, H Li, KM Quist, JJ Cherry… - Journal of medicinal …, 2017 - ACS Publications
Spinal muscular atrophy (SMA) is the leading genetic cause of infant death. We previously
developed a high-throughput assay that employs an SMN2-luciferase reporter allowing …

[HTML][HTML] In vitro and in vivo effects of 2, 4 diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS: context-specific modulation of SMN transcript levels

…, CA Menard, P Patel, R Ramos-Zayas, A Rietz… - PLoS …, 2017 - journals.plos.org
C5-substituted 2,4-diaminoquinazoline inhibitors of the decapping scavenger enzyme DcpS
(DAQ-DcpSi) have been developed for the treatment of spinal muscular atrophy (SMA), …

Optimization of a series of heterocycles as survival motor neuron gene transcription enhancers

…, EH Miller, KP Anderson, DK Fiejtek, A Rietz… - Bioorganic & medicinal …, 2017 - Elsevier
Spinal muscular atrophy (SMA) is a neurodegenerative disorder that results from mutations
in the SMN1 gene, leading to survival motor neuron (SMN) protein deficiency. One …

Short-duration splice promoting compound enables a tunable mouse model of spinal muscular atrophy

A Rietz, KJ Hodgetts, H Lusic, KM Quist… - Life Science …, 2021 - life-science-alliance.org
Spinal muscular atrophy (SMA) is a motor neuron disease and the leading genetic cause of
infant mortality. SMA results from insufficient survival motor neuron (SMN) protein due to …

The Function of E6BP in Normal Human and HPV-Infected Cell Lines

A Lima, A Rietz, EA Androphy - Proceedings of IMPRS, 2019 - journals.iupui.edu
Background and Hypothesis: High-risk human papillomavirus type-16 and-18 cause
approximately 70% of cervical and 60% of oropharyngeal cancers. While the majority of HPV …

Efficacy of Mutant HPV-16 E6 Proteins in p53 Degradation

C Lange, A Rietz, E Androphy - Proceedings of IMPRS, 2020 - journals.iupui.edu
Methods: E6 mutants were generated by site-directed mutagenesis and confirmed by
sequencing. H1299 cells were transfected with GFP, wild-type (WT) E6, or mutant HPV-16 E6 …