Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …

Since the mid 1970s, cancer has been described as a process of Darwinian evolution, with
somatic cellular selection and evolution being the fundamental processes leading to …

Abstract Systems biology is today such a widespread discipline that it becomes difficult to
propose a clear definition of what it really is. For some, it remains restricted to the genomic field…

Background Psychosocial symptoms often cluster together, are refractory to treatment, and
impair health‐related quality of life ( HR ‐QoL) in cancer patients. The contribution of …

The circadian clock coordinates biological and physiological functions to day/night cycles.
The perturbation of the circadian clock increases cancer risk and affects cancer progression. …

Scheduling anticancer drug administration over 24 h may critically impact treatment success
in a patient-specific manner. Here, we address personalization of treatment timing using a …

Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy. …

The least toxic time (LTT) of irinotecan varied by up to 8 hours according to sex and genetic
background in mice. The translational relevance was investigated within a randomized trial …

Cancer chronotherapy aims at enhancing tolerability and efficacy of anticancer drugs through
their delivery according to circadian clocks. However, mouse and patient data show that …

Circadian timing largely modifies efficacy and toxicity of many anticancer drugs. Recent
findings suggest that optimal circadian delivery patterns depend on the patient genetic …