The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy

…, F Popp, R Verbeek, M Masoodi, A Nicolaou… - International …, 2010 - Elsevier
There is growing interest in the use of mesenchymal stem cells (MSC) for immune therapy.
Clinical trials that use MSC for treatment of therapy resistant graft versus host disease, …

Immunosuppression in acutely decompensated cirrhosis is mediated by prostaglandin E2

…, R Garcia-Martinez, J Cordoba, A Nicolaou… - Nature medicine, 2014 - nature.com
Liver disease is one of the leading causes of death worldwide 1 . Patients with cirrhosis
display an increased predisposition to and mortality from infection due to multimodal defects in …

Bioactive lipid mediators in skin inflammation and immunity

AC Kendall, A Nicolaou - Progress in lipid research, 2013 - Elsevier
The skin is the primary barrier from the outside environment, protecting the host from injury,
infectious pathogens, water loss and solar ultraviolet radiation. In this role, it is supported by …

[HTML][HTML] Omega-3 polyunsaturated fatty acids protect against inflammation through production of LOX and CYP450 lipid mediators: relevance for major depression …

A Borsini, A Nicolaou, D Camacho-Muñoz… - Molecular …, 2021 - nature.com
Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) can exert antidepressant,
anti-inflammatory and neuroprotective properties, but the exact molecular mechanism …

[HTML][HTML] Lipidomics of oxidized polyunsaturated fatty acids

KA Massey, A Nicolaou - Free Radical Biology and Medicine, 2013 - Elsevier
Lipid mediators are produced from the oxidation of polyunsaturated fatty acids through enzymatic
and free radical-mediated reactions. When subject to oxygenation via cyclooxygenases…

[HTML][HTML] Gut-derived short-chain fatty acids modulate skin barrier integrity by promoting keratinocyte metabolism and differentiation

…, AC Kendall, A Wiederkehr, LP Nicod, A Nicolaou… - Mucosal …, 2022 - Elsevier
Barrier integrity is central to the maintenance of healthy immunological homeostasis. Impaired
skin barrier function is linked with enhanced allergen sensitization and the development …

Simultaneous lipidomic analysis of three families of bioactive lipid mediators leukotrienes, resolvins, protectins and related hydroxy‐fatty acids by liquid …

…, NA Petasis, CN Serhan, A Nicolaou - … Journal Devoted to …, 2008 - Wiley Online Library
Bioactive lipid mediators derived from polyunsaturated fatty acids (PUFA) exhibit a range of
tissue‐ and cell‐specific activities in many physiological and pathological processes. …

Targeted lipidomic strategies for oxygenated metabolites of polyunsaturated fatty acids

…, AC Kendall, EA Dennis, A Nicolaou - Biochimica et Biophysica …, 2015 - Elsevier
Oxidation of polyunsaturated fatty acids (PUFA) through enzymatic or non-enzymatic free
radical-mediated reactions can yield an array of lipid metabolites including eicosanoids, …

High pancreatic n-3 fatty acids prevent STZ-induced diabetes in fat-1 mice: inflammatory pathway inhibition

…, S Bellenger, A Bataille, KA Massey, A Nicolaou… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Because of confounding factors, the effects of dietary n-3 polyunsaturated fatty
acids (PUFA) on type 1 diabetes remain to be clarified. We therefore evaluated whether fat-1 …

Lipidomic analysis of twenty‐seven prostanoids and isoprostanes by liquid chromatography/electrospray tandem mass spectrometry

M Masoodi, A Nicolaou - … Devoted to the Rapid Dissemination of …, 2006 - Wiley Online Library
Prostanoids are potent mediators of many physiological and pathophysiological processes.
Of the many analytical methodologies used for their qualitative and quantitative analysis, …