To elucidate the deregulated functional modules that drive clear cell renal cell carcinoma (ccRCC),
we performed comprehensive genomic, epigenomic, transcriptomic, proteomic, and …

Cancer proteogenomics promises new insights into cancer biology and treatment efficacy by
integrating genomics, transcriptomics and protein profiling including modifications by mass …

A large proportion of biomedical research and the development of therapeutics is focused
on a small fraction of the human genome. In a strategic effort to map the knowledge gaps …

We present a proteogenomic study of 108 human papilloma virus (HPV)-negative head and
neck squamous cell carcinomas (HNSCCs). Proteomic analysis systematically catalogs …

Recent advances in mass spectrometry (MS) have enabled extensive analysis of cancer
proteomes. Here, we employed quantitative proteomics to profile protein expression across 24 …

Elucidation of endogenous cellular protein-protein interactions and their networks is most
desirable for biological studies. Here we report our study of endogenous human coregulator …

Many oncogenic insults deregulate RNA splicing, often leading to hypersensitivity of tumors
to spliceosome-targeted therapies (STTs). However, the mechanisms by which STTs …

Steroid receptor coactivator-3 (SRC-3/AIB1) is an oncogene frequently amplified and
overexpressed in breast cancers. Here we report that SRC-3 interacts with REGγ, a proteasome …

The current knowledge on how transcription factors ( TF s), the ultimate targets and executors
of cellular signalling pathways, are regulated by protein–protein interactions remains …

Immunoprecipitation followed by mass spectrometry (IP/MS) has recently emerged as a
preferred method in the analysis of protein complex components and cellular protein networks. …