An outstanding question is how cells control the number and size of membrane organelles.
The small GTPase Rab5 has been proposed to be a master regulator of endosome …

The endosomal system plays an essential role in cell homeostasis by controlling cellular
signaling, nutrient sensing, cell polarity and cell migration. However, its place in the regulation …

The liver maintains glucose and lipid homeostasis by adapting its metabolic activity to the
energy needs of the organism. Communication between hepatocytes and extracellular …

Delivery of short interfering RNAs (siRNAs) remains a key challenge in the development of
RNA interference (RNAi) therapeutics. A better understanding of the mechanisms of siRNA …

Lipid nanoparticles (LNPs) have proven to be highly efficient carriers of short-interfering
RNAs (siRNAs) to hepatocytes in vivo; however, the precise mechanism by which this efficient …

Exploring the cell biology of hepatocytes in vitro could be a powerful strategy to dissect the
molecular mechanisms underlying the structure and function of the liver in vivo. However, this …

In several cell types, specific membrane proteins are retained intracellularly and rapidly
redistributed to the surface in response to stimulation. In fat and muscle, the GLUT4 glucose …

Insulin maintains whole body blood glucose homeostasis, in part, by regulating the amount
of the GLUT4 glucose transporter on the cell surface of fat and muscle cells. Insulin induces …

The intracellularly stored GLUT4 glucose transporter is rapidly translocated to the cell surface
upon insulin stimulation. Regulation of GLUT4 distribution is key for the maintenance of …

… Author links open overlay panel Fabian Seebacher a b i , Anja Zeigerer b c d , Nora Kory
e f g h , Natalie Krahmer a b … 031L0114A to Anja Zeigerer. …