Intracellular pathogens and danger signals trigger the formation of inflammasomes, which
activate inflammatory caspases and induce pyroptosis. The anthrax lethal factor …

Nucleotide-binding domain and leucine-rich repeat pyrin-domain containing protein 1 (NLRP1)
is an inflammasome sensor that mediates the activation of caspase-1 to induce cytokine …

Inflammasomes are multiprotein complexes that activate inflammatory cytokines and induce
pyroptosis in response to intracellular danger‐associated signals. NLRP1 and CARD8 are …

Pathogen-related signals induce a number of cytosolic pattern-recognition receptors (PRRs)
to form canonical inflammasomes, which activate pro-caspase-1 and trigger pyroptotic cell …

NLRP1 and CARD8 are related cytosolic sensors that upon activation form supramolecular
signalling complexes known as canonical inflammasomes, resulting in caspase−1 activation, …

NLRP1 and CARD8 are related pattern-recognition receptors (PRRs) that detect intracellular
danger signals and form inflammasomes. Both undergo autoproteolysis, generating N-…

The dipeptidyl peptidases (DPPs) regulate hormones, cytokines, and neuropeptides by
cleaving dipeptides after proline from their amino termini. Due to technical challenges, many …

Inflammasomes are multiprotein complexes formed in response to pathogens. NLRP1 and
CARD8 are related proteins that form inflammasomes, but the pathogen-associated signal(s) …

Inflammasomes are multiprotein complexes that sense intracellular danger signals and
induce pyroptosis. CARD8 and NLRP1 are related inflammasomes that are repressed by the …

The danger signals that activate the NLRP1 inflammasome have not been established. Here,
we report that the oxidized, but not the reduced, form of thioredoxin-1 (TRX1) binds to …