Multifocal hyperplasia of interstitial cells of Cajal (ICC hyperplasia) is a precursor of hereditary
gastrointestinal stromal tumors (GISTs) in patients with germline mutations of c-KIT or …

Tumors have been thought to initiate as avascular aggregates of malignant cells that only
later induce vascularization. Recently, this classic concept of tumor angiogenesis has been …

Vascular endothelial growth factor (VEGF) is essential for the differentiation of the primitive
embryonic vascular system and has been implicated in the vascularization of organs. …

The mammalian target of rapamycin (mTOR) has become an interesting target for cancer
therapy through its influence on oncogenic signals, which involve phosphatidylinositol‐3‐…

Vascular endothelial growth factor (VEGF) is not only essential for vasculogenesis and
angiogenesis but also is a potent inducer of vascular permeability. Although a dissection of the …

Purpose: Inhibitors of heat-shock protein 90 (Hsp90) may interfere with oncogenic signaling
pathways, including Erk, Akt, and hypoxia-inducible factor-1α (HIF-1α). Because insulin-like …

BACKGROUND: The exact distribution of periprostatic autonomic nerves is under debate.
OBJECTIVE: To study the topographical anatomy of autonomic nerves of the periprostatic …

Oncogenic signaling through activation of epidermal growth factor receptor (EGFR), HER-2,
and hypoxia inducible-factor-1α (HIF-1α) has been implicated in gastric cancer growth and …

Objective: Pulmonary artery sarcomas are rare and usually fatal tumors. The diagnosis is
difficult and delayed in most cases. Newer imaging techniques could allow early diagnosis in …

Comprehensive expression analysis using microarrays has identified a number of differentially
expressed genes in smoke-exposed bronchial epithelium and non–small cell lung …