[HTML][HTML] Reactivated endogenous retroviruses promote protein aggregate spreading
S Liu, SE Heumüller, A Hossinger, SA Müller… - Nature …, 2023 - nature.com
Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases,
but the exact mechanisms of intercellular protein aggregate dissemination remain …
but the exact mechanisms of intercellular protein aggregate dissemination remain …
[HTML][HTML] Highly efficient intercellular spreading of protein misfolding mediated by viral ligand-receptor interactions
S Liu, A Hossinger, SE Heumüller, A Hornberger… - Nature …, 2021 - nature.com
Protein aggregates associated with neurodegenerative diseases have the ability to transmit
to unaffected cells, thereby templating their own aberrant conformation onto soluble …
to unaffected cells, thereby templating their own aberrant conformation onto soluble …
[HTML][HTML] Prion strains depend on different endocytic routes for productive infection
A Fehlinger, H Wolf, A Hossinger, Y Duernberger… - Scientific reports, 2017 - nature.com
Prions are unconventional agents composed of misfolded prion protein that cause fatal
neurodegenerative diseases in mammals. Prion strains induce specific neuropathological …
neurodegenerative diseases in mammals. Prion strains induce specific neuropathological …
Horizontal transmission of cytosolic Sup35 prions by extracellular vesicles
S Liu, A Hossinger, JP Hofmann, P Denner, IM Vorberg - MBio, 2016 - Am Soc Microbiol
Prions are infectious protein particles that replicate by templating their aggregated state
onto soluble protein of the same type. Originally identified as the causative agent of …
onto soluble protein of the same type. Originally identified as the causative agent of …
Prions on the run: How extracellular vesicles serve as delivery vehicles for self-templating protein aggregates
S Liu, A Hossinger, S Göbbels, IM Vorberg - Prion, 2017 - Taylor & Francis
Extracellular vesicles (EVs) are actively secreted, membrane-bound communication vehicles
that exchange biomolecules between cells. EVs also serve as dissemination vehicles for …
that exchange biomolecules between cells. EVs also serve as dissemination vehicles for …
[HTML][HTML] Propagation and dissemination strategies of transmissible spongiform encephalopathy agents in mammalian cells
…, AC Hornberger, AS Hebestreit, A Hossinger… - International Journal of …, 2022 - mdpi.com
Transmissible spongiform encephalopathies or prion disorders are fatal infectious diseases
that cause characteristic spongiform degeneration in the central nervous system. The …
that cause characteristic spongiform degeneration in the central nervous system. The …
[HTML][HTML] Deposition pattern and subcellular distribution of disease-associated prion protein in cerebellar organotypic slice cultures infected with scrapie
H Wolf, A Hossinger, A Fehlinger, S Büttner… - Frontiers in …, 2015 - frontiersin.org
Organotypic cerebellar slices represent a suitable model for characterizing and manipulating
prion replication in complex cell environments. Organotypic slices recapitulate prion …
prion replication in complex cell environments. Organotypic slices recapitulate prion …
Modulation of Glycosaminoglycans Affects PrPSc Metabolism but Does Not Block PrPSc Uptake
H Wolf, A Graßmann, R Bester, A Hossinger… - Journal of …, 2015 - Am Soc Microbiol
Mammalian prions are unconventional infectious agents composed primarily of the misfolded
aggregated host prion protein PrP, termed PrP Sc . Prions propagate by the recruitment …
aggregated host prion protein PrP, termed PrP Sc . Prions propagate by the recruitment …
Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cells
…, L Paulsen, A Hornberger, A Hossinger… - Life Science …, 2019 - life-science-alliance.org
Prions of lower eukaryotes are self-templating protein aggregates that replicate by
converting homotypic proteins into stable, tightly packed beta-sheet–rich protein assemblies. …
converting homotypic proteins into stable, tightly packed beta-sheet–rich protein assemblies. …
Endogenous retroviruses promote prion-like spreading of proteopathic seeds
S Liu, SE Heumüller, A Hossinger, SA Müller… - bioRxiv, 2022 - biorxiv.org
Endogenous retroviruses, remnants of viral germline infections, make up a substantial
proportion of the mammalian genome. While usually epigenetically silenced, retroelements can …
proportion of the mammalian genome. While usually epigenetically silenced, retroelements can …