The introduction of HER2-targeted therapy for breast and gastric patients with ERBB2 (HER2)
amplification/overexpression has led to dramatic improvements in oncologic outcomes. In …

The functional impact of the vast majority of cancer somatic mutations remains unknown,
representing a critical knowledge gap for implementing precision oncology. Here, we report the …

The identification and quantification of proteins lags behind DNA-sequencing methods in
scale, sensitivity, and dynamic range. Here, we show that sparse amino acid–sequence …

The anaplastic lymphoma kinase (ALK) gene plays an important physiologic role in the
development of the brain and can be oncogenically altered in several malignancies, including …

… Interestingly, even though the m-pyridine group can freely rotate and could be expected to
adopt a number of orientations, formation of polymers or other oligomers has not been observed …

Eicosanoids represent a family of active biolipids derived from arachidonic acid primarily
through the action of cytosolic phospholipase A2-α. Three major downstream pathways have …

The complement cascade is a part of the innate immune system that acts primarily to remove
pathogens and injured cells. However, complement activation is also peculiarly associated …

Endohedrally functionalized bis(pyridine) ligands show the ability to self-discriminate when
treated with coordinating metals to form self-assembled clusters. Self-sorting between …

MHC class II (MHCII) expression is usually restricted to APC but can be expressed by cancer
cells. We examined the effect of cancer cell–specific MHCII (csMHCII) expression in lung …

A combination of self‐complementary hydrogen bonding and metal–ligand interactions
allows stereocontrol in the self‐assembly of prochiral ligand scaffolds. A unique, non‐tetrahedral …