User profiles for Alfredo Castello
Alfredo CastellóMRC University of Glasgow Centre for Virus Research Verified email at glasgow.ac.uk Cited by 9550 |
[HTML][HTML] Insights into RNA biology from an atlas of mammalian mRNA-binding proteins
A Castello, B Fischer, K Eichelbaum, R Horos… - Cell, 2012 - cell.com
RNA-binding proteins (RBPs) determine RNA fate from synthesis to decay. Employing two
complementary protocols for covalent UV crosslinking of RBPs to RNA, we describe a …
complementary protocols for covalent UV crosslinking of RBPs to RNA, we describe a …
A brave new world of RNA-binding proteins
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …
A prenylated dsRNA sensor protects against severe COVID-19
INTRODUCTION Interferons (IFNs) are cytokines that are rapidly deployed in response to
invading pathogens. By initiating a signaling cascade that stimulates the expression of …
invading pathogens. By initiating a signaling cascade that stimulates the expression of …
[HTML][HTML] The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs
BM Beckmann, R Horos, B Fischer, A Castello… - Nature …, 2015 - nature.com
RNA-binding proteins (RBPs) exert a broad range of biological functions. To explore the
scope of RBPs across eukaryotic evolution, we determined the in vivo RBP repertoire of the …
scope of RBPs across eukaryotic evolution, we determined the in vivo RBP repertoire of the …
[PDF][PDF] System-wide profiling of RNA-binding proteins uncovers key regulators of virus infection
The compendium of RNA-binding proteins (RBPs) has been greatly expanded by the
development of RNA-interactome capture (RIC). However, it remained unknown if the complement …
development of RNA-interactome capture (RIC). However, it remained unknown if the complement …
[PDF][PDF] Comprehensive identification of RNA-binding domains in human cells
Mammalian cells harbor more than a thousand RNA-binding proteins (RBPs), with half of
these employing unknown modes of RNA binding. We developed RBDmap to determine the …
these employing unknown modes of RNA binding. We developed RBDmap to determine the …
[HTML][HTML] Global changes of the RNA-bound proteome during the maternal-to-zygotic transition in Drosophila
The maternal-to-zygotic transition (MZT) is a process that occurs in animal embryos at the
earliest developmental stages, during which maternally deposited mRNAs and other …
earliest developmental stages, during which maternally deposited mRNAs and other …
System-wide identification of RNA-binding proteins by interactome capture
A Castello, R Horos, C Strein, B Fischer… - Nature protocols, 2013 - nature.com
Owing to their preeminent biological functions, the repertoire of expressed RNA-binding
proteins (RBPs) and their activity states are highly informative about cellular systems. We have …
proteins (RBPs) and their activity states are highly informative about cellular systems. We have …
[PDF][PDF] hnRNPK recruits PCGF3/5-PRC1 to the Xist RNA B-repeat to establish polycomb-mediated chromosomal silencing
…, BA Kirmizitas, N Solcan, A Cerase, A Castello… - Molecular cell, 2017 - cell.com
The Polycomb-repressive complexes PRC1 and PRC2 play a key role in chromosome silencing
induced by the non-coding RNA Xist. Polycomb recruitment is initiated by the PCGF3/5-…
induced by the non-coding RNA Xist. Polycomb recruitment is initiated by the PCGF3/5-…
The RNA-binding protein repertoire of embryonic stem cells
RNA-binding proteins (RBPs) have essential roles in RNA-mediated gene regulation, and
yet annotation of RBPs is limited mainly to those with known RNA-binding domains. To …
yet annotation of RBPs is limited mainly to those with known RNA-binding domains. To …