User profiles for Alfredo Castello

Alfredo Castelló

MRC University of Glasgow Centre for Virus Research
Verified email at glasgow.ac.uk
Cited by 9550

[HTML][HTML] Insights into RNA biology from an atlas of mammalian mRNA-binding proteins

A Castello, B Fischer, K Eichelbaum, R Horos… - Cell, 2012 - cell.com
RNA-binding proteins (RBPs) determine RNA fate from synthesis to decay. Employing two
complementary protocols for covalent UV crosslinking of RBPs to RNA, we describe a …

A brave new world of RNA-binding proteins

MW Hentze, A Castello, T Schwarzl… - Nature reviews Molecular …, 2018 - nature.com
RNA-binding proteins (RBPs) are typically thought of as proteins that bind RNA through one
or multiple globular RNA-binding domains (RBDs) and change the fate or function of the …

A prenylated dsRNA sensor protects against severe COVID-19

…, ECY Wang, A Ho, I Davis, RF Jarrett, A Castello… - Science, 2021 - science.org
INTRODUCTION Interferons (IFNs) are cytokines that are rapidly deployed in response to
invading pathogens. By initiating a signaling cascade that stimulates the expression of …

[HTML][HTML] The RNA-binding proteomes from yeast to man harbour conserved enigmRBPs

BM Beckmann, R Horos, B Fischer, A Castello… - Nature …, 2015 - nature.com
RNA-binding proteins (RBPs) exert a broad range of biological functions. To explore the
scope of RBPs across eukaryotic evolution, we determined the in vivo RBP repertoire of the …

[PDF][PDF] System-wide profiling of RNA-binding proteins uncovers key regulators of virus infection

…, I Davis, B Fischer, S Mohammed, A Castello - Molecular cell, 2019 - cell.com
The compendium of RNA-binding proteins (RBPs) has been greatly expanded by the
development of RNA-interactome capture (RIC). However, it remained unknown if the complement …

[PDF][PDF] Comprehensive identification of RNA-binding domains in human cells

A Castello, B Fischer, CK Frese, R Horos, AM Alleaume… - Molecular cell, 2016 - cell.com
Mammalian cells harbor more than a thousand RNA-binding proteins (RBPs), with half of
these employing unknown modes of RNA binding. We developed RBDmap to determine the …

[HTML][HTML] Global changes of the RNA-bound proteome during the maternal-to-zygotic transition in Drosophila

…, I Gupta, J Krijgsveld, MW Hentze, A Castello… - Nature …, 2016 - nature.com
The maternal-to-zygotic transition (MZT) is a process that occurs in animal embryos at the
earliest developmental stages, during which maternally deposited mRNAs and other …

System-wide identification of RNA-binding proteins by interactome capture

A Castello, R Horos, C Strein, B Fischer… - Nature protocols, 2013 - nature.com
Owing to their preeminent biological functions, the repertoire of expressed RNA-binding
proteins (RBPs) and their activity states are highly informative about cellular systems. We have …

[PDF][PDF] hnRNPK recruits PCGF3/5-PRC1 to the Xist RNA B-repeat to establish polycomb-mediated chromosomal silencing

…, BA Kirmizitas, N Solcan, A Cerase, A Castello… - Molecular cell, 2017 - cell.com
The Polycomb-repressive complexes PRC1 and PRC2 play a key role in chromosome silencing
induced by the non-coding RNA Xist. Polycomb recruitment is initiated by the PCGF3/5-…

The RNA-binding protein repertoire of embryonic stem cells

…, S Föhr, B Fischer, KT You, A Castello… - Nature structural & …, 2013 - nature.com
RNA-binding proteins (RBPs) have essential roles in RNA-mediated gene regulation, and
yet annotation of RBPs is limited mainly to those with known RNA-binding domains. To …