User profiles for Alexa Burger
Alexa BurgerUniversity of Colorado Anschutz Medical Campus Verified email at cuanschutz.edu Cited by 2032 |
[HTML][HTML] TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers
Colon cancers frequently harbor KRAS mutations, yet only a subset of KRAS mutant colon
cancer cell lines are dependent upon KRAS signaling for survival. In a screen for kinases that …
cancer cell lines are dependent upon KRAS signaling for survival. In a screen for kinases that …
Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes
CRISPR-Cas9 enables efficient sequence-specific mutagenesis for creating somatic or germline
mutants of model organisms. Key constraints in vivo remain the expression and delivery …
mutants of model organisms. Key constraints in vivo remain the expression and delivery …
[HTML][HTML] Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury
…, L De Chiara, RR Guevara, A Burger… - Nature …, 2018 - nature.com
Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving
tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by …
tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by …
CrispRVariants charts the mutation spectrum of genome engineering experiments
CRISPR-Cas9 and related technologies enable the efficient alteration of genomic DNA at
targeted positions and are widely used in applications ranging from individual gene knockouts …
targeted positions and are widely used in applications ranging from individual gene knockouts …
[PDF][PDF] Podocyte regeneration driven by renal progenitors determines glomerular disease remission and can be pharmacologically enhanced
Podocyte loss is a general mechanism of glomerular dysfunction that initiates and drives the
progression of chronic kidney disease, which affects 10% of the world population. Here, we …
progression of chronic kidney disease, which affects 10% of the world population. Here, we …
[HTML][HTML] Chamber identity programs drive early functional partitioning of the heart
The vertebrate heart muscle (myocardium) develops from the first heart field (FHF) and
expands by adding second heart field (SHF) cells. While both lineages exist already in teleosts, …
expands by adding second heart field (SHF) cells. While both lineages exist already in teleosts, …
Differentiation of crescent-forming kidney progenitor cells into podocytes attenuates severe glomerulonephritis in mice
Crescentic glomerulonephritis is characterized by vascular necrosis and parietal epithelial
cell hyperplasia in the space surrounding the glomerulus, resulting in the formation of …
cell hyperplasia in the space surrounding the glomerulus, resulting in the formation of …
[HTML][HTML] A defect in the mitochondrial protein Mpv17 underlies the transparent casper zebrafish
The casper strain of zebrafish is widely used in studies ranging from cancer to neuroscience.
casper offers the advantage of relative transparency throughout adulthood, making it …
casper offers the advantage of relative transparency throughout adulthood, making it …
[HTML][HTML] Highly efficient DNA-free gene disruption in the agricultural pest Ceratitis capitata by CRISPR-Cas9 ribonucleoprotein complexes
The Mediterranean fruitfly Ceratitis capitata (medfly) is an invasive agricultural pest of high
economic impact and has become an emerging model for developing new genetic control …
economic impact and has become an emerging model for developing new genetic control …
[HTML][HTML] Conserved enhancers control notochord expression of vertebrate Brachyury
The cell type-specific expression of key transcription factors is central to development and
disease. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning, …
disease. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning, …