User profiles for Alexa Burger

Alexa Burger

University of Colorado Anschutz Medical Campus
Verified email at cuanschutz.edu
Cited by 2032

[HTML][HTML] TAK1 inhibition promotes apoptosis in KRAS-dependent colon cancers

A Singh, MF Sweeney, M Yu, A Burger, P Greninger… - Cell, 2012 - cell.com
Colon cancers frequently harbor KRAS mutations, yet only a subset of KRAS mutant colon
cancer cell lines are dependent upon KRAS signaling for survival. In a screen for kinases that …

Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes

A Burger, H Lindsay, A Felker, C Hess… - …, 2016 - journals.biologists.com
CRISPR-Cas9 enables efficient sequence-specific mutagenesis for creating somatic or germline
mutants of model organisms. Key constraints in vivo remain the expression and delivery …

[HTML][HTML] Endocycle-related tubular cell hypertrophy and progenitor proliferation recover renal function after acute kidney injury

…, L De Chiara, RR Guevara, A Burger… - Nature …, 2018 - nature.com
Acute kidney injury (AKI) is considered largely reversible based on the capacity of surviving
tubular cells to dedifferentiate and replace lost cells via cell division. Here we show by …

CrispRVariants charts the mutation spectrum of genome engineering experiments

H Lindsay, A Burger, B Biyong, A Felker, C Hess… - Nature …, 2016 - nature.com
CRISPR-Cas9 and related technologies enable the efficient alteration of genomic DNA at
targeted positions and are widely used in applications ranging from individual gene knockouts …

[PDF][PDF] Podocyte regeneration driven by renal progenitors determines glomerular disease remission and can be pharmacologically enhanced

…, F Becherucci, B Mazzinghi, A Sisti, S Romoli, A Burger… - Stem cell reports, 2015 - cell.com
Podocyte loss is a general mechanism of glomerular dysfunction that initiates and drives the
progression of chronic kidney disease, which affects 10% of the world population. Here, we …

[HTML][HTML] Chamber identity programs drive early functional partitioning of the heart

…, D Panáková, AA Werdich, G Musso, A Burger… - Nature …, 2015 - nature.com
The vertebrate heart muscle (myocardium) develops from the first heart field (FHF) and
expands by adding second heart field (SHF) cells. While both lineages exist already in teleosts, …

Differentiation of crescent-forming kidney progenitor cells into podocytes attenuates severe glomerulonephritis in mice

…, F Guzzi, L Maggi, F Annunziato, A Burger… - Science Translational …, 2022 - science.org
Crescentic glomerulonephritis is characterized by vascular necrosis and parietal epithelial
cell hyperplasia in the space surrounding the glomerulus, resulting in the formation of …

[HTML][HTML] A defect in the mitochondrial protein Mpv17 underlies the transparent casper zebrafish

G D'Agati, R Beltre, A Sessa, A Burger, Y Zhou… - Developmental …, 2017 - Elsevier
The casper strain of zebrafish is widely used in studies ranging from cancer to neuroscience.
casper offers the advantage of relative transparency throughout adulthood, making it …

[HTML][HTML] Highly efficient DNA-free gene disruption in the agricultural pest Ceratitis capitata by CRISPR-Cas9 ribonucleoprotein complexes

…, M Salvemini, H Lindsay, E Chiavacci, A Burger… - Scientific reports, 2017 - nature.com
The Mediterranean fruitfly Ceratitis capitata (medfly) is an invasive agricultural pest of high
economic impact and has become an emerging model for developing new genetic control …

[HTML][HTML] Conserved enhancers control notochord expression of vertebrate Brachyury

…, C Mosimann, Z Kozmik, A Burger - Nature …, 2023 - nature.com
The cell type-specific expression of key transcription factors is central to development and
disease. Brachyury/T/TBXT is a major transcription factor for gastrulation, tailbud patterning, …