Mitochondria play fundamental roles within cells, including energy provision, calcium
homeostasis, and the regulation of apoptosis. The transport of mitochondria by microtubule-based …

A proline-to-serine substitution at position 56 in the gene encoding vesicle-associated
membrane protein-associated protein B (VAPB; VAPBP56S) causes some dominantly inherited …

Understanding the mechanisms that control processing of the amyloid precursor protein (APP)
to produce amyloid-β (Aβ) peptide represents a key area of Alzheimer's disease research. …

There is growing interest in the link between axonal cargo transport and age-associated
neuronal dysfunction. The study of axonal transport in neurons of adult animals requires …

A fundamental question in cell biology is how cellular components are delivered to their
destination with spatial and temporal precision within the crowded cytoplasmic environment. …

Mitochondria-ER contact sites (MERCs) orchestrate many important cellular functions including
regulating mitochondrial quality control through mitophagy and mediating mitochondrial …

Defective transport of mitochondria in axons is implicated in the pathogenesis of several age-associated
neurodegenerative diseases. However, the regulation and function of axonal …

Miro GTPases control mitochondrial morphology, calcium homeostasis, and regulate mitochondrial
distribution by mediating their attachment to the kinesin and dynein motor complex. It …

Kinesin light chain 1 (KLC1) binds to the intracellular cytoplasmic domain of the type-1
membrane-spanning protein calsyntenin-1 (also known as alcadein-α) to mediate transport of a …

Axonal transport is the active process whereby neurons transport cargoes such as organelles
and proteins anterogradely from the cell body to the axon terminal and retrogradely in the …