[PDF][PDF] Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes

…, C Thériault, C Rulleau, J Lanoix, E Bonneil, A Feghaly… - Immunity, 2021 - cell.com
Acute myeloid leukemia (AML) has not benefited from innovative immunotherapies, mainly
because of the lack of actionable immune targets. Using an original proteogenomic approach…

[HTML][HTML] Integrated neural dynamics of sensorimotor decisions and actions

D Thura, JF Cabana, A Feghaly, P Cisek - PLoS biology, 2022 - journals.plos.org
Recent theoretical models suggest that deciding about actions and executing them are not
implemented by completely distinct neural mechanisms but are instead two modes of an …

[HTML][HTML] Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs

MP Hardy, É Audemard, F Migneault, A Feghaly… - Scientific reports, 2019 - nature.com
Endothelial cells have multifaceted interactions with the immune system, both as initiators
and targets of immune responses. In vivo, apoptotic endothelial cells release two types of …

[HTML][HTML] UM171 expansion of cord blood improves donor availability and HLA matching for all patients, including minorities

M Dumont-Lagacé, A Feghaly, MC Meunier… - … and Cellular Therapy, 2022 - Elsevier
Cord blood (CB) stem cell transplantation offers a greater tolerance to HLA mismatches
compared to adult-derived stem cell transplants (ie, bone marrow or peripheral blood stem cells). …

Targeted variant detection using unaligned RNA-Seq reads

EO Audemard, P Gendron, A Feghaly… - Life Science …, 2019 - life-science-alliance.org
Mutations identified in acute myeloid leukemia patients are useful for prognosis and for selecting
targeted therapies. Detection of such mutations using next-generation sequencing data …

Unified neural dynamics of decisions and actions in the cerebral cortex and basal ganglia

D Thura, JF Cabana, A Feghaly, P Cisek - BioRxiv, 2020 - biorxiv.org
Several theoretical models suggest that deciding about actions and executing them are not
completely distinct neural mechanisms but instead two modes of an integrated dynamical …

The sequence features that define efficient and specific hAGO2-dependent miRNA silencing guides

…, J Quenneville, J Robitaille, A Feghaly… - Nucleic acids …, 2018 - academic.oup.com
MicroRNAs (miRNAs) are ribonucleic acids (RNAs) of ∼21 nucleotides that interfere with
the translation of messenger RNAs (mRNAs) and play significant roles in development and …

L‐n‐acetyl‐cysteine protection against cisplatin‐induced auditory neuronal and hair cell toxicity

JG Feghali, W Liu, TR Van De Water - The Laryngoscope, 2001 - Wiley Online Library
Objectives The aim of this study is to determine the efficacy of L‐N‐acetyl‐cysteine (L‐NAC)
as a protectant for inner ear auditory sensory cells against the toxic effects of cisplatin. Study …

Long-term severe hypoxia adaptation induces non-canonical EMT and a novel Wilms Tumor 1 (WT1) isoform.

E Gagnon, J Quenneville, A Feghaly, M Tual, F Major - 2023 - researchsquare.com
The majority of cancer deaths are caused by solid tumors, where the four most prevalent
cancers (breast, lung, colorectal and prostate) account for more than 60% of all cases (1). …

[HTML][HTML] CAMAP: Artificial neural networks unveil the role of codon arrangement in modulating MHC-I peptides presentation

T Daouda, M Dumont-Lagacé, A Feghaly… - PLoS Computational …, 2021 - journals.plos.org
MHC-I associated peptides (MAPs) play a central role in the elimination of virus-infected and
neoplastic cells by CD8 T cells. However, accurately predicting the MAP repertoire remains …