Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2 E3 ligase activity to Cdt1

A Hayashi, NN Giakoumakis… - Life Science …, 2018 - life-science-alliance.org
The CRL4 Cdt2 ubiquitin ligase complex is an essential regulator of cell-cycle progression
and genome stability, ubiquitinating substrates such as p21, Set8, and Cdt1, via a display of …

Two different replication factor C proteins, Ctf18 and RFC1, separately control PCNA-CRL4Cdt2-mediated Cdt1 proteolysis during S phase and following UV …

Y Shiomi, A Hayashi, T Ishii, K Shinmyozu… - … and cellular biology, 2012 - Am Soc Microbiol
Recent work identified the E3 ubiquitin ligase CRL4 Cdt2 as mediating the timely degradation
of Cdt1 during DNA replication and following DNA damage. In both cases, proliferating …

[HTML][HTML] Inhibition of DNA damage-induced apoptosis through Cdc7-mediated stabilization of Tob

T Suzuki, J Tsuzuku, A Hayashi, Y Shiomi… - Journal of Biological …, 2012 - ASBMB
Cells respond to DNA damage by activating alternate signaling pathways that induce
proliferation arrest or apoptosis. The correct balance between these two pathways is important for …

Mismatch repair proteins recruited to ultraviolet light-damaged sites lead to degradation of licensing factor Cdt1 in the G1 phase

M Tanaka, M Takahara, K Nukina, A Hayashi, W Sakai… - Cell Cycle, 2017 - Taylor & Francis
Cdt1 is rapidly degraded by CRL4 Cdt2 E3 ubiquitin ligase after UV (UV) irradiation. Previous
reports revealed that the nucleotide excision repair (NER) pathway is responsible for the …

Paleomagnetic results and K-Ar dating on Miocene rocks in the northern part of Fukui Prefecture, Central Japan with reference to the rotation of Southwest Japan

…, Y Sawada, T Nakagawa, A Hayashi… - Journal of Mineralogy …, 1990 - jstage.jst.go.jp
K-Ar age determination and paleomagnetic measurement have been carried out on the
Miocene rocks distributed in Fukui Prefecture, the northeastern part of Southwest Japan. …

Cross‐linked polyvinylpyrrolidones with increased affinity and specificity for methyl orange and its homologs

T Takagishi, A Hayashi, N Kuroki - Journal of Polymer Science …, 1982 - Wiley Online Library
Polyvinylpyrrolidones of various degrees of cross‐linkage have been prepared by radical
polymerization of N‐vinylpyrrolidone with methylenebisacrylamide to regulate the fraction of …

Diuretic action of paeonol

…, Y Miwa, M Kimura, K Mizutani, A Hayashi… - Planta …, 1985 - thieme-connect.com
Abstract Effects of paeonol, a major component of the root bark of Paeonia suffruticosa, on
urinary excretion of water (UV), sodium (U Na V), potassium (UKV), chloride (U cl V) and …

NMR-spectral studies of 2-linked glycosides: 2-O-glycosylation shifts of 2-O-glycosylated α-and β-l-arabinopyranosides

K Mizutani, A Hayashi, R Kasai, O Tanaka… - Carbohydrate …, 1984 - Elsevier
Anomalous glycosylation shift values of the signals for C-1 (the anomeric carbon atom) and
C-2 (the glycosyloxylated carbon atom) were sometimes observed for 2-O-β-d-…

Mutations at multiple CDK phosphorylation consensus sites on Cdt2 increase the affinity of CRL4Cdt2 for PCNA and its ubiquitination activity in S phase

K Nukina, A Hayashi, Y Shiomi, K Sugasawa… - Genes to …, 2018 - Wiley Online Library
CRL4 Cdt2 ubiquitin ligase plays an important role maintaining genome integrity during the
cell cycle. A recent report suggested that Cdk1 negatively regulates CRL4 Cdt2 activity …

Interaction of crosslinked polyethylenimine with a homologous series of methyl orange derivatives in aqueous solution

T Takagishi, T Sugimoto, A Hayashi… - Journal of Polymer …, 1983 - Wiley Online Library
Polyethylenimine (PEI) was crosslinked with dichloroethane, glyoxal, or glutaraldehyde and
polymers of various degrees of crosslinkage were made. The insoluble polymers obtained …