Circadian rhythms are daily cycles of physiology and behaviour that are driven by an
endogenous oscillator with a period of approximately (circa-) one day (diem). Exemplified in …

Cellular life emerged ∼3.7 billion years ago. With scant exception, terrestrial organisms
have evolved under predictable daily cycles owing to the Earth’s rotation. The advantage …

Background: Genes encoding the circadian pacemaker in the hypothalamic suprachiasmatic
nuclei (SCN) of mammals have recently been identified, but the molecular basis of …

Circadian (∼24 hour) clocks are fundamentally important for coordinated physiology in
organisms as diverse as cyanobacteria and humans. All current models of the molecular …

Circadian rhythms are essential to health. Their disruption is associated with metabolic diseases
in experimental animals and man [1–3]. Local metabolic rhythms represent an output of …

Circadian rhythms are ubiquitous in eukaryotes, and coordinate numerous aspects of
behaviour, physiology and metabolism, from sleep/wake cycles in mammals to growth and …

Circadian timekeeping in mammals is driven by transcriptional/posttranslational feedback
loops [1] that are active within both peripheral tissues and the circadian pacemaker of the …

Importance Sleep disturbances are recognized as a common nonmotor complaint in
Parkinson disease but their etiology is poorly understood. Objective To define the sleep and …

Circadian control of physiology is mediated by local, tissue‐based clocks, synchronized to
each other and to solar time by signals from the suprachiasmatic nuclei (SCN), the master …

Genome biology approaches have made enormous contributions to our understanding of
biological rhythms, particularly in identifying outputs of the clock, including RNAs, proteins, and …