Aging is characterized by the development of metabolic dysfunction and frailty. Recent studies
show that a reduction in nicotinamide adenine dinucleotide (NAD + ) is a key factor for the …

Muscle wasting is a decline in skeletal muscle mass and function that is associated with aging,
obesity, and a spectrum of pathologies including cancer. Cancer-associated wasting not …

miR-486 is a muscle-enriched microRNA, or “myomiR,” that has reduced expression
correlated with Duchenne muscular dystrophy (DMD). To determine the function of miR-486 in …

DOCK3 is a member of the DOCK family of guanine nucleotide exchange factors that
regulate cell migration, fusion and viability. Previously, we identified a dysregulated miR-486/…

Background Muscle wasting is a debilitating co‐morbidity affecting most advanced cancer
patients. Alongside enhanced muscle catabolism, defects in muscle repair/regeneration …

Duchenne muscular dystrophy (DMD) is a progressive, X-linked childhood neuromuscular
disorder that results from loss-of-function mutations in the DYSTROPHIN gene. DMD patients …

The Dedicator of Cytokinesis (DOCK) family (DOCK1−11) of genes are essential mediators
of cellular migration, growth, and fusion in a variety of cell types and tissues. Recent …

DOCK (dedicator of cytokinesis) is an 11-member family of typical guanine nucleotide exchange
factors (GEFs) expressed in the brain, spinal cord, and skeletal muscle. Several DOCK …

Duchenne muscular dystrophy (DMD) is an X-linked progressive muscle disorder resulting
in muscle weakness and cardiomyopathy. MicroRNAs have been shown to play essential …

DOCK (dedicator of cytokinesis) proteins are an 11-member family of typical guanine
exchange factors (GEFs) expressed in the brain and spinal cord. Several DOCK proteins have …