User profiles for Adam L Hughes

Adam L Hughes

Associate Professor, University of Utah
Verified email at biochem.utah.edu
Cited by 3559

An early age increase in vacuolar pH limits mitochondrial function and lifespan in yeast

AL Hughes, DE Gottschling - Nature, 2012 - nature.com
Mitochondria have a central role in ageing. They are considered to be both a target of the
ageing process and a contributor to it 1 . Alterations in mitochondrial structure and function are …

Mother-daughter asymmetry of pH underlies aging and rejuvenation in yeast

KA Henderson, AL Hughes, DE Gottschling - Elife, 2014 - elifesciences.org
10.7554/eLife.03504.001 Replicative aging in yeast is asymmetric–mother cells age but their
daughter cells are rejuvenated. Here we identify an asymmetry in pH between mother and …

Regulation of sterol synthesis in eukaryotes

PJ Espenshade, AL Hughes - Annu. Rev. Genet., 2007 - annualreviews.org
Cholesterol is an essential component of mammalian cell membranes and is required for
proper membrane permeability, fluidity, organelle identity, and protein function. Cells maintain …

[PDF][PDF] Cysteine toxicity drives age-related mitochondrial decline by altering iron homeostasis

CE Hughes, TK Coody, MY Jeong, JA Berg, DR Winge… - Cell, 2020 - cell.com
… Further information and requests for resources and reagents should be directed to and will
be fulfilled by the Lead Contact, Adam L. Hughes (hughes@biochem.utah.edu). All unique/…

[HTML][HTML] SREBP pathway responds to sterols and functions as an oxygen sensor in fission yeast

AL Hughes, BL Todd, PJ Espenshade - Cell, 2005 - cell.com
Cholesterol and fatty acid synthesis in mammals are controlled by SREBPs, a family of
membrane bound transcription factors. Our studies identified homologs of SREBP, its binding …

[PDF][PDF] Dap1/PGRMC1 binds and regulates cytochrome P450 enzymes

AL Hughes, DW Powell, M Bard, J Eckstein, R Barbuch… - Cell metabolism, 2007 - cell.com
Cytochrome P450 enzymes are heme-dependent monoxygenases that play a central role in
human physiology. Despite the numerous physiological processes that P450 enzymes …

[HTML][HTML] Systematic mapping of contact sites reveals tethers and a function for the peroxisome-mitochondria contact

…, L Zada, MC Mari, FM Reggiori, AL Hughes… - Nature …, 2018 - nature.com
The understanding that organelles are not floating in the cytosol, but rather held in an organized
yet dynamic interplay through membrane contact sites, is altering the way we grasp cell …

[HTML][HTML] The crucial impact of lysosomes in aging and longevity

D Carmona-Gutierrez, AL Hughes, F Madeo… - Ageing research …, 2016 - Elsevier
Lysosomes are the main catabolic organelles of a cell and play a pivotal role in a plethora
of cellular processes, including responses to nutrient availability and composition, stress …

Sterol regulatory element binding protein is a principal regulator of anaerobic gene expression in fission yeast

BL Todd, EV Stewart, JS Burg, AL Hughes… - … and cellular biology, 2006 - Taylor & Francis
Fission yeast sterol regulatory element binding protein (SREBP), called Sre1p, functions in
an oxygen-sensing pathway to allow adaptation to fluctuating oxygen concentrations. The …

Exploiting multiple levels of parallelism in molecular dynamics based calculations via modern techniques and software paradigms on distributed memory computers

…, DA Yarne, SO Samuelson, AL Hughes… - Computer Physics …, 2000 - Elsevier
Modern Molecular Dynamics methods are employed to study quantum manybody systems,
chemically reactive systems including explicit electronic degrees of freedom, and …