User profiles for Achim Kramer

Achim Kramer

Laboratory of Chronobiology, Charité Universitätsmedizin Berlin
Verified email at charite.de
Cited by 12212

A circadian clock in macrophages controls inflammatory immune responses

…, ED Herzog, HD Volk, A Kramer… - Proceedings of the …, 2009 - National Acad Sciences
Time of day-dependent variations of immune system parameters are ubiquitous phenomena
in immunology. The circadian clock has been attributed with coordinating these variations …

[HTML][HTML] High-accuracy determination of internal circadian time from a single blood sample

…, S Kadener, D Kunz, A Kramer - The Journal of …, 2018 - Am Soc Clin Investig
BACKGROUND. The circadian clock is a fundamental and pervasive biological program that
coordinates 24-hour rhythms in physiology, metabolism, and behavior, and it is essential to …

Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling

A Kramer, FC Yang, P Snodgrass, X Li, TE Scammell… - Science, 2001 - science.org
The circadian clock in the suprachiasmatic nucleus (SCN) is thought to drive daily rhythms of
behavior by secreting factors that act locally within the hypothalamus. In a systematic screen…

[PDF][PDF] Spontaneous synchronization of coupled circadian oscillators

D Gonze, S Bernard, C Waltermann, A Kramer… - Biophysical journal, 2005 - cell.com
In mammals, the circadian pacemaker, which controls daily rhythms, is located in the
suprachiasmatic nucleus (SCN). Circadian oscillations are generated in individual SCN neurons by …

Differential effects of PER2 phosphorylation: molecular basis for the human familial advanced sleep phase syndrome (FASPS)

…, H Herzel, A Schlosser, A Kramer - Genes & …, 2006 - genesdev.cshlp.org
PERIOD (PER) proteins are central components within the mammalian circadian oscillator,
and are believed to form a negative feedback complex that inhibits their own transcription at …

Coupling governs entrainment range of circadian clocks

…, PO Westermark, M Heine, A Kramer… - Molecular systems …, 2010 - embopress.org
Circadian clocks are endogenous oscillators driving daily rhythms in physiology and
behavior. Synchronization of these timers to environmental light–dark cycles (‘entrainment’) is …

[HTML][HTML] Regulation of clock-controlled genes in mammals

…, A Relógio, SM Kielbasa, M Heine, C Dame, A Kramer… - PloS one, 2009 - journals.plos.org
The complexity of tissue- and day time-specific regulation of thousands of clock-controlled
genes (CCGs) suggests that many regulatory mechanisms contribute to the transcriptional …

Molecular insights into human daily behavior

…, H Herzel, A Kramer - Proceedings of the …, 2008 - National Acad Sciences
Human beings exhibit wide variation in their timing of daily behavior. We and others have
suggested previously that such differences might arise because of alterations in the period …

[HTML][HTML] Synchronization-induced rhythmicity of circadian oscillators in the suprachiasmatic nucleus

…, B Čajavec, H Herzel, A Kramer - PLoS computational …, 2007 - journals.plos.org
The suprachiasmatic nuclei (SCN) host a robust, self-sustained circadian pacemaker that
coordinates physiological rhythms with the daily changes in the environment. Neuronal clocks …

Circadian behavior is light-reprogrammed by plastic DNA methylation

…, H Rehrauer, A Patrignani, B Maier, A Kramer… - Nature …, 2014 - nature.com
The timing of daily circadian behavior can be highly variable among different individuals, and
twin studies have suggested that about half of this variability is environmentally controlled. …