A beginner's guide to analyzing and visualizing mass cytometry data

AK Kimball, LM Oko, BL Bullock… - The Journal of …, 2018 - journals.aai.org
Mass cytometry has revolutionized the study of cellular and phenotypic diversity, significantly
expanding the number of phenotypic and functional characteristics that can be measured at …

Targeting DDR2 enhances tumor response to anti–PD-1 immunotherapy

MM Tu, FYF Lee, RT Jones, AK Kimball, E Saravia… - Science …, 2019 - science.org
While a fraction of cancer patients treated with anti–PD-1 show durable therapeutic responses,
most remain unresponsive, highlighting the need to better understand and improve these …

Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti–PD-1 response in NSCLC

BL Bullock, AK Kimball, JM Poczobutt… - Life science …, 2019 - life-science-alliance.org
Targeting PD-1/PD-L1 is only effective in ∼20% of lung cancer patients, but determinants of
this response are poorly defined. We previously observed differential responses of two …

Host‐associated bacterial community succession during amphibian development

TL Prest, AK Kimball, JG Kueneman… - Molecular …, 2018 - Wiley Online Library
Amphibians undergo significant developmental changes during their life cycle, as they typically
move from a primarily aquatic environment to a more terrestrial one. Amphibian skin is a …

[HTML][HTML] Cancer cell-intrinsic expression of MHC II in lung cancer cell lines is actively restricted by MEK/ERK signaling and epigenetic mechanisms

AJ Neuwelt, AK Kimball, AM Johnson… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background Programmed death 1/programmed death ligand 1 (PD-1/PD-L1) targeted
immunotherapy affords clinical benefit in~ 20% of unselected patients with lung cancer. The factor …

Sphingosine-1-phosphate lyase inhibition alters the S1P gradient and ameliorates Crohn's-like ileitis by suppressing thymocyte maturation

…, T Pérez-Jeldres, AK Kimball… - Inflammatory Bowel …, 2020 - academic.oup.com
Background Lymphocytes recirculate from tissues to blood following the sphingosine-1-phosphate
(S1P) gradient (low in tissues, high in blood), maintained by synthetic and …

[HTML][HTML] High-dimensional characterization of IL-10 production and IL-10–dependent regulation during primary gammaherpesvirus infection

AK Kimball, LM Oko, RE Kaspar, LF van Dyk… - …, 2019 - journals.aai.org
IL-10 is a potent immunomodulatory cytokine produced by multiple cell types to restrain
immune activation. Many herpesviruses use the IL-10 pathway to facilitate infection, but how …

[HTML][HTML] Multidimensional analysis of Gammaherpesvirus RNA expression reveals unexpected heterogeneity of gene expression

LM Oko, AK Kimball, RE Kaspar, AN Knox… - PLoS …, 2019 - journals.plos.org
Virus-host interactions are frequently studied in bulk cell populations, obscuring cell-to-cell
variation. Here we investigate endogenous herpesvirus gene expression at the single-cell …

[HTML][HTML] High-dimensional analysis of postsplenectomy peripheral immune cell changes

…, VM Vorwald, JM Smith, DM Davis, AK Kimball… - …, 2020 - journals.aai.org
Although the consequences of splenectomy are well understood in mice, much less is known
about the immunologic changes that occur following splenectomy in humans. We sought to …

Redefining de novo gammaherpesvirus infection through high-dimensional, single-cell analysis of virus and host

JN Berger, B Sanford, AK Kimball, LM Oko, RE Kaspar… - bioRxiv, 2020 - biorxiv.org
Virus infection is frequently characterized using bulk cell populations. How these findings
correspond to infection in individual cells remains unclear. Here, we integrate high-…