Increasing energy expenditure through activation of endogenous brown adipose tissue (BAT)
is a potential approach to treat obesity and diabetes. The class of β3-adrenergic receptor (…

Background Obesity results from an imbalance between energy intake and expenditure. In
rodents and newborn humans, brown adipose tissue helps regulate energy expenditure by …

Reassessing Human Adipose Tissue Adipose tissue can more than double in mass and
then return to baseline. This review discusses the functional roles of human white and brown …

BACKGROUND Mirabegron is a β3-adrenergic receptor (β3-AR) agonist approved only for
the treatment of overactive bladder. Encouraging preclinical results suggest that β3-AR …

The imbalance between energy intake and expenditure is the underlying cause of the
current obesity and diabetes pandemics. Central to these pathologies is the fat depot: white …

Obesity develops when energy intake exceeds energy expenditure. Although most current
obesity therapies are focused on reducing calorific intake, recent data suggest that increasing …

Human brown adipose tissue (BAT) can be activated to increase glucose uptake and energy
expenditure, making it a potential target for treating obesity and metabolic disease. Data on …

Brown adipose tissue (BAT) acts in mammals as a natural defense system against
hypothermia, and its activation to a state of increased energy expenditure is believed to protect …

Adult humans have functional BAT, a new target for antiobesity and antidiabetes therapies
focusing on increasing energy expenditure. Future studies will refine the methodologies used …

Maintenance of body temperature is essential for the survival of homeotherms. Brown adipose
tissue (BAT) is a specialized fat tissue that is dedicated to thermoregulation 1 . Owing to …