Unexplored therapeutic opportunities in the human genome
A large proportion of biomedical research and the development of therapeutics is focused
on a small fraction of the human genome. In a strategic effort to map the knowledge gaps …
on a small fraction of the human genome. In a strategic effort to map the knowledge gaps …
[PDF][PDF] Proteogenomic insights into the biology and treatment of HPV-negative head and neck squamous cell carcinoma
…, T Liu, H Liu, W Ma, E Malc, A Malovannaya… - Cancer cell, 2021 - cell.com
We present a proteogenomic study of 108 human papilloma virus (HPV)-negative head and
neck squamous cell carcinomas (HNSCCs). Proteomic analysis systematically catalogs …
neck squamous cell carcinomas (HNSCCs). Proteomic analysis systematically catalogs …
[PDF][PDF] Integrated proteogenomic characterization of clear cell renal cell carcinoma
…, AG Paulovich, AM Perou, A Malovannaya… - Cell, 2019 - cell.com
To elucidate the deregulated functional modules that drive clear cell renal cell carcinoma (ccRCC),
we performed comprehensive genomic, epigenomic, transcriptomic, proteomic, and …
we performed comprehensive genomic, epigenomic, transcriptomic, proteomic, and …
[HTML][HTML] Analysis of the human endogenous coregulator complexome
A Malovannaya, RB Lanz, SY Jung, Y Bulynko, NT Le… - Cell, 2011 - cell.com
Elucidation of endogenous cellular protein-protein interactions and their networks is most
desirable for biological studies. Here we report our study of endogenous human coregulator …
desirable for biological studies. Here we report our study of endogenous human coregulator …
[HTML][HTML] The SRC-3/AIB1 coactivator is degraded in a ubiquitin-and ATP-independent manner by the REGγ proteasome
Steroid receptor coactivator-3 (SRC-3/AIB1) is an oncogene frequently amplified and
overexpressed in breast cancers. Here we report that SRC-3 interacts with REGγ, a proteasome …
overexpressed in breast cancers. Here we report that SRC-3 interacts with REGγ, a proteasome …
[PDF][PDF] Spliceosome-targeted therapies trigger an antiviral immune response in triple-negative breast cancer
Many oncogenic insults deregulate RNA splicing, often leading to hypersensitivity of tumors
to spliceosome-targeted therapies (STTs). However, the mechanisms by which STTs …
to spliceosome-targeted therapies (STTs). However, the mechanisms by which STTs …
[HTML][HTML] Proteogenomic integration reveals therapeutic targets in breast cancer xenografts
…, MD McLellan, MC Wendl, A Malovannaya… - Nature …, 2017 - nature.com
Recent advances in mass spectrometry (MS) have enabled extensive analysis of cancer
proteomes. Here, we employed quantitative proteomics to profile protein expression across 24 …
proteomes. Here, we employed quantitative proteomics to profile protein expression across 24 …
[PDF][PDF] Proteomic analysis of coregulators bound to ERα on DNA and nucleosomes reveals coregulator dynamics
…, C Ding, S Bailey, TL Hunsaker, A Malovannaya… - Molecular cell, 2013 - cell.com
Chromatin immunoprecipitation studies have mapped protein occupancies at many genomic
loci. However, a detailed picture of the complexity of coregulators (CoRs) bound to a …
loci. However, a detailed picture of the complexity of coregulators (CoRs) bound to a …
Proteomic analyses reveal distinct chromatin‐associated and soluble transcription factor complexes
The current knowledge on how transcription factors ( TF s), the ultimate targets and executors
of cellular signalling pathways, are regulated by protein–protein interactions remains …
of cellular signalling pathways, are regulated by protein–protein interactions remains …
[HTML][HTML] Microscaled proteogenomic methods for precision oncology
…, R Schiff, J Hoog, S Jacobs, A Malovannaya… - Nature …, 2020 - nature.com
Cancer proteogenomics promises new insights into cancer biology and treatment efficacy by
integrating genomics, transcriptomics and protein profiling including modifications by mass …
integrating genomics, transcriptomics and protein profiling including modifications by mass …