ADP is a key agonist in hemostasis and thrombosis. ADP-induced platelet activation involves
the purinergic P2Y 1 receptor, which is responsible for shape change through intracellular …

Platelet dense-granules are small organelles specific to the platelet lineage that contain small
molecules (calcium, adenyl nucleotides, serotonin) and are essential for the activation of …

See also Brill A. A ride with ferric chloride. This issue, pp 776–8. Summary Background: The
FeCl 3 ‐induced vascular injury model is widely used to study thrombogenesis in vivo, but …

Citrate is the preferred anticoagulant for blood collection, as EDTA damages platelets and
heparin modifies their function ( 1 ). Citrate allows the rapid generation of platelet-rich plasma (…

Mutations in the MYH9 gene encoding the nonmuscle myosin heavy chain IIA result in bleeding
disorders characterized by a macrothrombocytopenia. To understand the role of myosin …

The demarcation membrane system (DMS) in megakaryocytes forms the plasma membrane
(PM) of future platelets. Using confocal microscopy, electron tomography, and large volume …

Binding of coagulation factors to phosphatidylserine (PS)-exposing procoagulant-activated
platelets followed by formation of the membrane-dependent enzyme complexes is critical for …

Recently we showed that the P2Y 1 receptor coupled to calcium mobilization is necessary
to initiate ADP‐induced human platelet aggregation. Since the thienopyridine compound …

While the adenosine 5′-diphosphate (ADP) pathway is known to enhance thrombus formation
by recruiting platelets and leukocytes to the primary layer of collagen-adhering platelets, …

Platelets activated by ADP become refractory to restimulation, but the mechanism of this
process is not well understood. A normal platelet response to ADP requires coactivation of the …