Oncogene-induced senescence (OIS) is crucial for tumour suppression. Senescent cells
implement a complex pro-inflammatory response termed the senescence-associated secretory …

The immunosuppressive protein PD-L1 is upregulated in many cancers and contributes to
evasion of the host immune system. The relative importance of the tumor microenvironment …

RNA interference is widely distributed in eukaryotes and has a variety of functions, including
antiviral defence and gene regulation 1 , 2 . All RNA interference pathways use small single-…

… Although dNotum is only expressed in a vertical band along the A–P boundary, it spreads
along the whole A–P axis. d, Ectopic dNotum represses Senseless expression in dlp mutants …

S phase and mitotic onset are brought about by the action of multiple different cyclin-CDK
complexes. However, it has been suggested that changes in the total level of CDK kinase …

… We observed a lower proportion of AP-positive cells among Cbx7+/À … 4 days and stained
with AP. Representative images were taken and the percentage of AP-positive colonies of the …

Intestinal failure, following extensive anatomical or functional loss of small intestine, has
debilitating long-term consequences for children 1 . The priority of patient care is to increase the …

Macroautophagy requires membrane trafficking and remodelling to form the autophagosome
and deliver its contents to lysosomes for degradation. We have previously identified the …

In order to facilitate the identification of factors and pathways in the cellular response to UV-induced
DNA damage, several descriptive proteomic screens and a functional genomics …

ATG9A is a multispanning membrane protein essential for autophagy. Normally resident in
Golgi membranes and endosomes, during amino acid starvation, ATG9A traffics to sites of …