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GEO help: Mouse over screen elements for information. |
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Status |
Public on Mar 08, 2012 |
Title |
Integrated bioinformatic and wet-lab approach to identify potential oncogenic networks in neuroblastoma |
Organism |
Homo sapiens |
Experiment type |
Expression profiling by array
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Summary |
mRNA profiles of thousands of human tumors are available, but methods to deduce oncogenic signaling networks from these data lag behind. It is especially challenging to identify main-regulatory routes, and to generalize conclusions obtained from experimental models. We designed the bioinformatic platform R2 in parallel with a wet-lab approach of neuroblastoma. Here we demonstrate how R2 facilitates an integrated analysis of our neuroblastoma data. Analysis of the MYCN pathway suggested important regulatory connections to the polyamine synthesis route, the Notch pathway and the BMP/TGFβ pathway. A network of genes emerged connecting major oncogenes in neuroblastoma. Genes in the network carried strong prognostic values and were essential for tumor cell survival.
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Overall design |
88 human Neuroblastoma samples were analyzed.
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Contributor(s) |
Versteeg R |
Citation(s) |
22367537, 23908688, 23042116, 25315710, 22788920 |
Submission date |
Jun 07, 2009 |
Last update date |
Feb 13, 2020 |
Contact name |
Linda Valentijn |
Organization name |
Academic Medical Centre, University of Amsterdam
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Department |
Department of Oncogenomics
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Street address |
P.O. Box 22700
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City |
Amsterdam |
ZIP/Postal code |
1100DE |
Country |
Netherlands |
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Platforms (1) |
GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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Samples (88)
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GSM414003 |
Neuroblastoma, #4 |
GSM414004 |
Neuroblastoma, #5 |
GSM414005 |
Neuroblastoma, #6 |
GSM414006 |
Neuroblastoma, #7 |
GSM414007 |
Neuroblastoma, #8 |
GSM414008 |
Neuroblastoma, #9 |
GSM414009 |
Neuroblastoma, #10 |
GSM414010 |
Neuroblastoma, #11 |
GSM414011 |
Neuroblastoma, #12 |
GSM414012 |
Neuroblastoma, #13 |
GSM414013 |
Neuroblastoma, #14 |
GSM414014 |
Neuroblastoma, #15 |
GSM414015 |
Neuroblastoma, #16 |
GSM414016 |
Neuroblastoma, #17 |
GSM414017 |
Neuroblastoma, #18 |
GSM414018 |
Neuroblastoma, #19 |
GSM414019 |
Neuroblastoma, #20 |
GSM414020 |
Neuroblastoma, #21 |
GSM414021 |
Neuroblastoma, #22 |
GSM414022 |
Neuroblastoma, #23 |
GSM414023 |
Neuroblastoma, #24 |
GSM414024 |
Neuroblastoma, #25 |
GSM414025 |
Neuroblastoma, #26 |
GSM414026 |
Neuroblastoma, #27 |
GSM414027 |
Neuroblastoma, #28 |
GSM414028 |
Neuroblastoma, #29 |
GSM414029 |
Neuroblastoma, #30 |
GSM414030 |
Neuroblastoma, #31 |
GSM414031 |
Neuroblastoma, #32 |
GSM414032 |
Neuroblastoma, #33 |
GSM414033 |
Neuroblastoma, #34 |
GSM414034 |
Neuroblastoma, #35 |
GSM414035 |
Neuroblastoma, #36 |
GSM414036 |
Neuroblastoma, #37 |
GSM414037 |
Neuroblastoma, #38 |
GSM414038 |
Neuroblastoma, #39 |
GSM414039 |
Neuroblastoma, #40 |
GSM414040 |
Neuroblastoma, #41 |
GSM414041 |
Neuroblastoma, #42 |
GSM414042 |
Neuroblastoma, #43 |
GSM414043 |
Neuroblastoma, #44 |
GSM414044 |
Neuroblastoma, #45 |
GSM414045 |
Neuroblastoma, #46 |
GSM414046 |
Neuroblastoma, #47 |
GSM414047 |
Neuroblastoma, #48 |
GSM414048 |
Neuroblastoma, #49 |
GSM414049 |
Neuroblastoma, #50 |
GSM414050 |
Neuroblastoma, #51 |
GSM414051 |
Neuroblastoma, #52 |
GSM414052 |
Neuroblastoma, #53 |
GSM414053 |
Neuroblastoma, #54 |
GSM414054 |
Neuroblastoma, #55 |
GSM414055 |
Neuroblastoma, #56 |
GSM414056 |
Neuroblastoma, #57 |
GSM414057 |
Neuroblastoma, #58 |
GSM414058 |
Neuroblastoma, #59 |
GSM414059 |
Neuroblastoma, #60 |
GSM414060 |
Neuroblastoma, #61 |
GSM414061 |
Neuroblastoma, #62 |
GSM414062 |
Neuroblastoma, #63 |
GSM414063 |
Neuroblastoma, #64 |
GSM414064 |
Neuroblastoma, #65 |
GSM414065 |
Neuroblastoma, #66 |
GSM414066 |
Neuroblastoma, #67 |
GSM414067 |
Neuroblastoma, #68 |
GSM414068 |
Neuroblastoma, #69 |
GSM414069 |
Neuroblastoma, #70 |
GSM414070 |
Neuroblastoma, #71 |
GSM414071 |
Neuroblastoma, #72 |
GSM414072 |
Neuroblastoma, #73 |
GSM414073 |
Neuroblastoma, #74 |
GSM414074 |
Neuroblastoma, #75 |
GSM414075 |
Neuroblastoma, #76 |
GSM414076 |
Neuroblastoma, #77 |
GSM414077 |
Neuroblastoma, #78 |
GSM414078 |
Neuroblastoma, #79 |
GSM414079 |
Neuroblastoma, #80 |
GSM414080 |
Neuroblastoma, #81 |
GSM414081 |
Neuroblastoma, #82 |
GSM414082 |
Neuroblastoma, #83 |
GSM414083 |
Neuroblastoma, #84 |
GSM414084 |
Neuroblastoma, #85 |
GSM414085 |
Neuroblastoma, #86 |
GSM414086 |
Neuroblastoma, #87 |
GSM414087 |
Neuroblastoma, #88 |
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This SubSeries is part of SuperSeries: |
GSE16254 |
Integrated bioinformatic and wet-lab approach to identify potential oncogenic networks in neuroblastoma and other tumors |
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Relations |
BioProject |
PRJNA122889 |
Supplementary file |
Size |
Download |
File type/resource |
GSE16476_RAW.tar |
411.6 Mb |
(http)(custom) |
TAR (of CEL) |
Processed data included within Sample table |
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