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Series GSE16476 Query DataSets for GSE16476
Status Public on Mar 08, 2012
Title Integrated bioinformatic and wet-lab approach to identify potential oncogenic networks in neuroblastoma
Organism Homo sapiens
Experiment type Expression profiling by array
Summary mRNA profiles of thousands of human tumors are available, but methods to deduce oncogenic signaling networks from these data lag behind. It is especially challenging to identify main-regulatory routes, and to generalize conclusions obtained from experimental models. We designed the bioinformatic platform R2 in parallel with a wet-lab approach of neuroblastoma. Here we demonstrate how R2 facilitates an integrated analysis of our neuroblastoma data. Analysis of the MYCN pathway suggested important regulatory connections to the polyamine synthesis route, the Notch pathway and the BMP/TGFβ pathway. A network of genes emerged connecting major oncogenes in neuroblastoma. Genes in the network carried strong prognostic values and were essential for tumor cell survival.
 
Overall design 88 human Neuroblastoma samples were analyzed.
 
Contributor(s) Versteeg R
Citation(s) 22367537, 23908688, 23042116, 25315710, 22788920
Submission date Jun 07, 2009
Last update date Feb 13, 2020
Contact name Linda Valentijn
Organization name Academic Medical Centre, University of Amsterdam
Department Department of Oncogenomics
Street address P.O. Box 22700
City Amsterdam
ZIP/Postal code 1100DE
Country Netherlands
 
Platforms (1)
GPL570 [HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array
Samples (88)
GSM414000 Neuroblastoma, #1
GSM414001 Neuroblastoma, #2
GSM414002 Neuroblastoma, #3
This SubSeries is part of SuperSeries:
GSE16254 Integrated bioinformatic and wet-lab approach to identify potential oncogenic networks in neuroblastoma and other tumors
Relations
BioProject PRJNA122889

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE16476_RAW.tar 411.6 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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