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USP16 is an ISG15 cross-reactive deubiquitinase that targets pro-ISG15 and ISGylated proteins involved in metabolism.
Gan J, Pinto-Fernández A, Flierman D, Akkermans JJLL, O'Brien DP, Greenwood H, Scott HC, Fritz G, Knobeloch KP, Neefjes J, van Dam H, Ovaa H, Ploegh HL, Kessler BM, Geurink PP, Sapmaz A. Gan J, et al. Among authors: scott hc. Proc Natl Acad Sci U S A. 2023 Dec 12;120(50):e2315163120. doi: 10.1073/pnas.2315163120. Epub 2023 Dec 6. Proc Natl Acad Sci U S A. 2023. PMID: 38055744
Deletion of the deISGylating enzyme USP18 enhances tumour cell antigenicity and radiosensitivity.
Pinto-Fernandez A, Salio M, Partridge T, Chen J, Vere G, Greenwood H, Olie CS, Damianou A, Scott HC, Pegg HJ, Chiarenza A, Díaz-Saez L, Smith P, Gonzalez-Lopez C, Patel B, Anderton E, Jones N, Hammonds TR, Huber K, Muschel R, Borrow P, Cerundolo V, Kessler BM. Pinto-Fernandez A, et al. Among authors: scott hc. Br J Cancer. 2021 Feb;124(4):817-830. doi: 10.1038/s41416-020-01167-y. Epub 2020 Nov 20. Br J Cancer. 2021. PMID: 33214684 Free PMC article.
USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma.
Ruiz EJ, Pinto-Fernandez A, Turnbull AP, Lan L, Charlton TM, Scott HC, Damianou A, Vere G, Riising EM, Da Costa C, Krajewski WW, Guerin D, Kearns JD, Ioannidis S, Katz M, McKinnon C, O'Connell J, Moncaut N, Rosewell I, Nye E, Jones N, Heride C, Gersch M, Wu M, Dinsmore CJ, Hammonds TR, Kim S, Komander D, Urbe S, Clague MJ, Kessler BM, Behrens A. Ruiz EJ, et al. Among authors: scott hc. Elife. 2021 Oct 12;10:e71596. doi: 10.7554/eLife.71596. Elife. 2021. PMID: 34636321 Free PMC article.
Cerebro-Spinal Fever.
Scott HC. Scott HC. J Natl Med Assoc. 1931 Apr;23(2):83-5. J Natl Med Assoc. 1931. PMID: 20892454 Free PMC article. No abstract available.
USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation.
Rusilowicz-Jones EV, Jardine J, Kallinos A, Pinto-Fernandez A, Guenther F, Giurrandino M, Barone FG, McCarron K, Burke CJ, Murad A, Martinez A, Marcassa E, Gersch M, Buckmelter AJ, Kayser-Bricker KJ, Lamoliatte F, Gajbhiye A, Davis S, Scott HC, Murphy E, England K, Mortiboys H, Komander D, Trost M, Kessler BM, Ioannidis S, Ahlijanian MK, Urbé S, Clague MJ. Rusilowicz-Jones EV, et al. Among authors: scott hc. Life Sci Alliance. 2020 Jul 7;3(8):e202000768. doi: 10.26508/lsa.202000768. Print 2020 Aug. Life Sci Alliance. 2020. PMID: 32636217 Free PMC article.
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