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ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastoma.
Ferrarese R, Izzo A, Andrieux G, Lagies S, Bartmuss JP, Masilamani AP, Wasilenko A, Osti D, Faletti S, Schulzki R, Yuan S, Kling E, Ribecco V, Heiland DH, Tholen S, Prinz M, Pelicci G, Kammerer B, Boerries M, Carro MS. Ferrarese R, et al. Among authors: schulzki r. Life Sci Alliance. 2022 Nov 22;6(1):e202201400. doi: 10.26508/lsa.202201400. Print 2023 Jan. Life Sci Alliance. 2022. PMID: 36414381 Free PMC article.
Calpain-mediated cleavage generates a ZBTB18 N-terminal product that regulates HIF1A signaling and glioblastoma metabolism.
Masilamani AP, Schulzki R, Yuan S, Haase IV, Kling E, Dewes F, Andrieux G, Börries M, Schnell O, Heiland DH, Schilling O, Ferrarese R, Carro MS. Masilamani AP, et al. Among authors: schulzki r. iScience. 2022 Jun 17;25(7):104625. doi: 10.1016/j.isci.2022.104625. eCollection 2022 Jul 15. iScience. 2022. PMID: 35800763 Free PMC article.