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Cancer regulatory variation.
Hennessey RC, Brown KM. Hennessey RC, et al. Curr Opin Genet Dev. 2021 Feb;66:41-49. doi: 10.1016/j.gde.2020.11.010. Epub 2021 Jan 7. Curr Opin Genet Dev. 2021. PMID: 33422949 Review.
UVB mutagenesis differs in Nras- and Braf-mutant mouse models of melanoma.
Bowman RL, Hennessey RC, Weiss TJ, Tallman DA, Crawford ER, Murphy BM, Webb A, Zhang S, La Perle KM, Burd CJ, Levine RL, Shain AH, Burd CE. Bowman RL, et al. Among authors: hennessey rc. Life Sci Alliance. 2021 Jul 1;4(9):e202101135. doi: 10.26508/lsa.202101135. Print 2021 Sep. Life Sci Alliance. 2021. PMID: 34210801 Free PMC article.
Cell-intrinsic melanin fails to protect melanocytes from ultraviolet-mutagenesis in the absence of epidermal melanin.
Weiss TJ, Crawford ER, Posada V, Rahman H, Liu T, Murphy BM, Arnold TE, Gray S, Hu Z, Hennessey RC, Yu L, D'Orazio JA, Burd CJ, Zippin JH, Grossman D, Burd CE. Weiss TJ, et al. Among authors: hennessey rc. Pigment Cell Melanoma Res. 2023 Jan;36(1):6-18. doi: 10.1111/pcmr.13070. Epub 2022 Oct 9. Pigment Cell Melanoma Res. 2023. PMID: 36148789 Free PMC article.
Massively parallel reporter assays of melanoma risk variants identify MX2 as a gene promoting melanoma.
Choi J, Zhang T, Vu A, Ablain J, Makowski MM, Colli LM, Xu M, Hennessey RC, Yin J, Rothschild H, Gräwe C, Kovacs MA, Funderburk KM, Brossard M, Taylor J, Pasaniuc B, Chari R, Chanock SJ, Hoggart CJ, Demenais F, Barrett JH, Law MH, Iles MM, Yu K, Vermeulen M, Zon LI, Brown KM. Choi J, et al. Among authors: hennessey rc. Nat Commun. 2020 Jun 1;11(1):2718. doi: 10.1038/s41467-020-16590-1. Nat Commun. 2020. PMID: 32483191 Free PMC article.
A UVB-responsive common variant at chromosome band 7p21.1 confers tanning response and melanoma risk via regulation of the aryl hydrocarbon receptor, AHR.
Xu M, Mehl L, Zhang T, Thakur R, Sowards H, Myers T, Jessop L, Chesi A, Johnson ME, Wells AD, Michael HT, Bunda P, Jones K, Higson H, Hennessey RC, Jermusyk A, Kovacs MA, Landi MT, Iles MM, Goldstein AM; Melanoma Meta-Analysis Consortium; Choi J, Chanock SJ, Grant SFA, Chari R, Merlino G, Law MH, Brown KM. Xu M, et al. Among authors: hennessey rc. Am J Hum Genet. 2021 Sep 2;108(9):1611-1630. doi: 10.1016/j.ajhg.2021.07.002. Epub 2021 Aug 2. Am J Hum Genet. 2021. PMID: 34343493 Free PMC article.
The Exportin-1 Inhibitor Selinexor Exerts Superior Antitumor Activity when Combined with T-Cell Checkpoint Inhibitors.
Farren MR, Hennessey RC, Shakya R, Elnaggar O, Young G, Kendra K, Landesman Y, Elloul S, Crochiere M, Klebanov B, Kashyap T, Burd CE, Lesinski GB. Farren MR, et al. Among authors: hennessey rc. Mol Cancer Ther. 2017 Mar;16(3):417-427. doi: 10.1158/1535-7163.MCT-16-0498. Epub 2017 Feb 1. Mol Cancer Ther. 2017. PMID: 28148715 Free PMC article.