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Drug screen in iPSC-Neurons identifies nucleoside analogs as inhibitors of (G4C2)n expression in C9orf72 ALS/FTD.
Czuppa M, Dhingra A, Zhou Q, Schludi C, König L, Scharf E, Farny D, Dalmia A, Täger J, Castillo-Lizardo M, Katona E, Mori K, Aumer T, Schelter F, Müller M, Carell T, Kalliokoski T, Messinger J, Rizzu P, Heutink P, Edbauer D. Czuppa M, et al. Cell Rep. 2022 Jun 7;39(10):110913. doi: 10.1016/j.celrep.2022.110913. Cell Rep. 2022. PMID: 35675776 Free article.
Cell-to-cell transmission of C9orf72 poly-(Gly-Ala) triggers key features of ALS/FTD.
Khosravi B, LaClair KD, Riemenschneider H, Zhou Q, Frottin F, Mareljic N, Czuppa M, Farny D, Hartmann H, Michaelsen M, Arzberger T, Hartl FU, Hipp MS, Edbauer D. Khosravi B, et al. Among authors: czuppa m. EMBO J. 2020 Apr 15;39(8):e102811. doi: 10.15252/embj.2019102811. Epub 2020 Mar 16. EMBO J. 2020. PMID: 32175624 Free PMC article.
Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model.
Zhou Q, Mareljic N, Michaelsen M, Parhizkar S, Heindl S, Nuscher B, Farny D, Czuppa M, Schludi C, Graf A, Krebs S, Blum H, Feederle R, Roth S, Haass C, Arzberger T, Liesz A, Edbauer D. Zhou Q, et al. Among authors: czuppa m. EMBO Mol Med. 2020 Feb 7;12(2):e10919. doi: 10.15252/emmm.201910919. Epub 2019 Dec 20. EMBO Mol Med. 2020. PMID: 31858749 Free PMC article.
Single cell RNA sequencing to dissect the molecular heterogeneity in lupus nephritis.
Der E, Ranabothu S, Suryawanshi H, Akat KM, Clancy R, Morozov P, Kustagi M, Czuppa M, Izmirly P, Belmont HM, Wang T, Jordan N, Bornkamp N, Nwaukoni J, Martinez J, Goilav B, Buyon JP, Tuschl T, Putterman C. Der E, et al. Among authors: czuppa m. JCI Insight. 2017 May 4;2(9):e93009. doi: 10.1172/jci.insight.93009. eCollection 2017 May 4. JCI Insight. 2017. PMID: 28469080 Free PMC article.