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MLL1 is regulated by KSHV LANA and is important for virus latency.
Tan M, Li S, Juillard F, Chitas R, Custódio TF, Xue H, Szymula A, Sun Q, Liu B, Álvarez ÁL, Chen S, Huang J, Simas JP, McVey CE, Kaye KM. Tan M, et al. Among authors: custodio tf. Nucleic Acids Res. 2021 Dec 16;49(22):12895-12911. doi: 10.1093/nar/gkab1094. Nucleic Acids Res. 2021. PMID: 34850113 Free PMC article.
Form factor determination of biological molecules with X-ray free electron laser small-angle scattering (XFEL-SAS).
Blanchet CE, Round A, Mertens HDT, Ayyer K, Graewert M, Awel S, Franke D, Dörner K, Bajt S, Bean R, Custódio TF, de Wijn R, Juncheng E, Henkel A, Gruzinov A, Jeffries CM, Kim Y, Kirkwood H, Kloos M, Knoška J, Koliyadu J, Letrun R, Löw C, Makroczyova J, Mall A, Meijers R, Pena Murillo GE, Oberthür D, Round E, Seuring C, Sikorski M, Vagovic P, Valerio J, Wollweber T, Zhuang Y, Schulz J, Haas H, Chapman HN, Mancuso AP, Svergun D. Blanchet CE, et al. Among authors: custodio tf. Commun Biol. 2023 Oct 18;6(1):1057. doi: 10.1038/s42003-023-05416-7. Commun Biol. 2023. PMID: 37853181 Free PMC article.
Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2.
Custódio TF, Das H, Sheward DJ, Hanke L, Pazicky S, Pieprzyk J, Sorgenfrei M, Schroer MA, Gruzinov AY, Jeffries CM, Graewert MA, Svergun DI, Dobrev N, Remans K, Seeger MA, McInerney GM, Murrell B, Hällberg BM, Löw C. Custódio TF, et al. Nat Commun. 2020 Nov 4;11(1):5588. doi: 10.1038/s41467-020-19204-y. Nat Commun. 2020. PMID: 33149112 Free PMC article.
Deamidation drives molecular aging of the SARS-CoV-2 spike protein receptor-binding motif.
Lorenzo R, Defelipe LA, Aliperti L, Niebling S, Custódio TF, Löw C, Schwarz JJ, Remans K, Craig PO, Otero LH, Klinke S, García-Alai M, Sánchez IE, Alonso LG. Lorenzo R, et al. Among authors: custodio tf. J Biol Chem. 2021 Oct;297(4):101175. doi: 10.1016/j.jbc.2021.101175. Epub 2021 Sep 7. J Biol Chem. 2021. PMID: 34499924 Free PMC article.
KSHV but not MHV-68 LANA induces a strong bend upon binding to terminal repeat viral DNA.
Ponnusamy R, Petoukhov MV, Correia B, Custodio TF, Juillard F, Tan M, Pires de Miranda M, Carrondo MA, Simas JP, Kaye KM, Svergun DI, McVey CE. Ponnusamy R, et al. Among authors: custodio tf. Nucleic Acids Res. 2015 Nov 16;43(20):10039-54. doi: 10.1093/nar/gkv987. Epub 2015 Sep 30. Nucleic Acids Res. 2015. PMID: 26424851 Free PMC article.