Notes from some crypt watchers: regulation of renewal in the mouse intestinal epithelium

T S Stappenbeck; M H Wong; J R Saam; I U Mysorekar; J I Gordon

doi:10.1016/s0955-0674(98)80110-5

Notes from some crypt watchers: regulation of renewal in the mouse intestinal epithelium

Curr Opin Cell Biol. 1998 Dec;10(6):702-9. doi: 10.1016/s0955-0674(98)80110-5.

Authors

T S Stappenbeck¹, M H Wong, J R Saam, I U Mysorekar, J I Gordon

Affiliation

¹ Department of Molecular Biology and Pharmacology Washington University School of Medicine St. Louis MO 63110 USA.

PMID: 9914172
DOI: 10.1016/s0955-0674(98)80110-5

Abstract

The mouse intestinal epithelium undergoes rapid renewal throughout life, thereby requiring continuous coordination of its cellular proliferation, differentiation, and death programs. Recent advances in our understanding of this process have highlighted some of the molecules that regulate renewal and their potential roles in gut neoplasia.

Publication types

Review

MeSH terms

Animals
Cell Division / genetics
Colorectal Neoplasms / genetics
Colorectal Neoplasms / pathology
Epithelial Cells / cytology
Epithelial Cells / metabolism
Epithelial Cells / pathology
Gene Expression Regulation, Neoplastic
Genes, APC / genetics
Intestinal Mucosa / cytology*
Intestinal Mucosa / pathology
Intestinal Polyps / genetics
Intestinal Polyps / pathology
Intestine, Small / cytology*
Intestine, Small / pathology
Mice