Abstract
TRAIL (TNF-related-apoptosis-inducing-ligand) was found as a new member of the TNF family which mediates cell death in a wide variety of malignant cell lines and primary tumor cells. TRAIL induces two different signals, cell death mediated by caspases and gene induction mediated by NFkappaB. Inhibition of TRAIL-induced activation of NFkappaB augments apoptosis induction by TRAIL and attenuates apoptosis resistance.
MeSH terms
-
Animals
-
Apoptosis / drug effects*
-
Apoptosis / physiology
-
Apoptosis Regulatory Proteins
-
Gene Expression Regulation / drug effects
-
Humans
-
Membrane Glycoproteins / pharmacology*
-
Membrane Glycoproteins / physiology
-
NF-kappa B / metabolism*
-
Receptors, Tumor Necrosis Factor / physiology
-
Signal Transduction
-
TNF-Related Apoptosis-Inducing Ligand
-
Transcriptional Activation
-
Tumor Necrosis Factor-alpha / pharmacology*
-
Tumor Necrosis Factor-alpha / physiology
Substances
-
Apoptosis Regulatory Proteins
-
Membrane Glycoproteins
-
NF-kappa B
-
Receptors, Tumor Necrosis Factor
-
TNF-Related Apoptosis-Inducing Ligand
-
TNFSF10 protein, human
-
Tumor Necrosis Factor-alpha