Abstract
Exit from mitosis requires the inactivation of mitotic cyclin-dependent kinases (CDKs) by an unknown mechanism. We show that the Cdc14 phosphatase triggers mitotic exit by three parallel mechanisms, each of which inhibits Cdk activity. Cdc14 dephosphorylates Sic1, a Cdk inhibitor, and Swi5, a transcription factor for SIC1, and induces degradation of mitotic cyclins, likely by dephosphorylating the activator of mitotic cyclin degradation, Cdh1/Hct1. Feedback between these pathways may lead to precipitous collapse of mitotic CDK activity and help coordinate exit from mitosis.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anaphase-Promoting Complex-Cyclosome
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Cdh1 Proteins
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Cell Cycle Proteins / genetics
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Cell Cycle Proteins / physiology*
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Cyclin B*
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Cyclin-Dependent Kinase Inhibitor Proteins
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Cyclin-Dependent Kinases / metabolism*
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Cyclins / metabolism
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DNA Replication / genetics
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DNA-Binding Proteins*
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Fungal Proteins / metabolism
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Fungal Proteins / physiology
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GTP-Binding Proteins
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Gene Expression Regulation, Enzymologic
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Gene Expression Regulation, Fungal
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Ligases / metabolism
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Ligases / physiology
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Mitosis / physiology*
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Mutation
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Phosphoprotein Phosphatases / genetics
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Phosphoprotein Phosphatases / physiology
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Phosphorylation
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Protein Kinases / physiology
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Protein Serine-Threonine Kinases
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Protein Tyrosine Phosphatases*
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RNA-Binding Proteins
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Recombinant Fusion Proteins / genetics
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Saccharomyces cerevisiae / cytology
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Saccharomyces cerevisiae / enzymology*
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Saccharomyces cerevisiae / genetics
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Saccharomyces cerevisiae Proteins*
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Substrate Specificity
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Transcription Factors / metabolism
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Transcription, Genetic
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Ubiquitin-Protein Ligase Complexes*
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Ubiquitin-Protein Ligases
Substances
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CDC14 protein, S cerevisiae
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CDC15 protein
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CDH1 protein, S cerevisiae
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CEF1 protein, S cerevisiae
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CLB2 protein, S cerevisiae
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Cdh1 Proteins
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Cell Cycle Proteins
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Cyclin B
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Cyclin-Dependent Kinase Inhibitor Proteins
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Cyclins
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DNA-Binding Proteins
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Fungal Proteins
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RNA-Binding Proteins
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Recombinant Fusion Proteins
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SIC1 protein, S cerevisiae
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SWI5 protein, S cerevisiae
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Saccharomyces cerevisiae Proteins
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Transcription Factors
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Ubiquitin-Protein Ligase Complexes
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Anaphase-Promoting Complex-Cyclosome
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Ubiquitin-Protein Ligases
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Protein Kinases
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DBF2 protein, S cerevisiae
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Protein Serine-Threonine Kinases
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Cyclin-Dependent Kinases
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Phosphoprotein Phosphatases
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Protein Tyrosine Phosphatases
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GTP-Binding Proteins
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Ligases