Abstract
Cancer cells show characteristic telomere dynamics. Their chromosomes usually have short telomeres and a high telomerase activity. The "telomere crisis model" proposed here suggests that these unique telomeric features are responsible for the progression of cancer.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Blotting, Southern
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Cell Transformation, Neoplastic
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Chromosomes, Human / physiology
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Chromosomes, Human / ultrastructure
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DNA, Neoplasm / genetics
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Humans
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Mutation
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Neoplasms / enzymology
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Neoplasms / genetics
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Neoplasms / pathology
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Neoplasms / physiopathology*
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Philadelphia Chromosome
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Repetitive Sequences, Nucleic Acid
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Telomerase / metabolism*
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Telomere / pathology
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Telomere / physiology*