A human RNA polymerase II complex associated with SRB and DNA-repair proteins

E Maldonado; R Shiekhattar; M Sheldon; H Cho; R Drapkin; P Rickert; E Lees; C W Anderson; S Linn; D Reinberg

doi:10.1038/381086a0

A human RNA polymerase II complex associated with SRB and DNA-repair proteins

Nature. 1996 May 2;381(6577):86-9. doi: 10.1038/381086a0.

Authors

E Maldonado¹, R Shiekhattar, M Sheldon, H Cho, R Drapkin, P Rickert, E Lees, C W Anderson, S Linn, D Reinberg

Affiliation

¹ Howard Hughes Medical Institute, Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Piscataway 08854-5635, USA.

PMID: 8609996
DOI: 10.1038/381086a0

Abstract

We report here the isolation of a human RNA polymerase II complex containing a subset of the basal transcription factors and the human homologues of the yeast SRB (for suppressors of RNA polymerase B) proteins. The complex contains transcriptional coactivators and increases the activation of transcription. In addition, some components of the RNA polymerase II complex participate in DNA repair.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Chromatography, Affinity
DNA Repair*
HeLa Cells
Humans
Molecular Sequence Data
Protein Binding
RNA Polymerase II / metabolism*
Recombinant Proteins / metabolism
Transcription Factor TFIIH
Transcription Factors / metabolism*
Transcription Factors, TFII*
Transcription, Genetic

Substances

Recombinant Proteins
Transcription Factors
Transcription Factors, TFII
Transcription Factor TFIIH
RNA Polymerase II

Associated data

GENBANK/U52960