Abstract
The remarkable T cell receptor (TCR) performs essential functions in the initiation of intracellular signals required for T cell development, repertoire selection and effector responses to foreign antigens. How TCR signals elicit such diverse cellular responses and outcomes remains a major question for investigation. Recent years have witnessed important advances in our understanding of the regulatory processes that control and modulate the TCR signalling response. Here, we review newly identified mechanisms for the regulation of TCR signalling and then discuss how the TCR signalling response is regulated to control two critical cellular processes - namely, positive selection and T cell homeostasis.
Publication types
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Research Support, N.I.H., Intramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Adaptor Proteins, Signal Transducing / immunology
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Animals
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Antigens, CD / immunology
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Calcineurin / immunology
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Cell Differentiation / immunology
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Feedback, Physiological
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Humans
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Lymphocyte Specific Protein Tyrosine Kinase p56(lck) / immunology
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Models, Immunological
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Receptors, Antigen, T-Cell / immunology*
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Signal Transduction / immunology
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T-Lymphocytes / cytology
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T-Lymphocytes / immunology*
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T-Lymphocytes / metabolism
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Ubiquitination
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ZAP-70 Protein-Tyrosine Kinase / immunology
Substances
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Adaptor Proteins, Signal Transducing
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Antigens, CD
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Receptors, Antigen, T-Cell
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Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
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ZAP-70 Protein-Tyrosine Kinase
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Calcineurin