Nuclear export of RNA: Different sizes, shapes and functions

Tobias Williams; Linh H Ngo; Vihandha O Wickramasinghe

doi:10.1016/j.semcdb.2017.08.054

Nuclear export of RNA: Different sizes, shapes and functions

Semin Cell Dev Biol. 2018 Mar:75:70-77. doi: 10.1016/j.semcdb.2017.08.054. Epub 2017 Sep 1.

Authors

Tobias Williams¹, Linh H Ngo¹, Vihandha O Wickramasinghe²

Affiliations

¹ RNA Biology and Cancer Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia.
² RNA Biology and Cancer Laboratory, Peter MacCallum Cancer Centre, Melbourne, Victoria 3000, Australia. Electronic address: vi.wickramasinghe@petermac.org.

PMID: 28866329
DOI: 10.1016/j.semcdb.2017.08.054

Abstract

Export of protein-coding and non-coding RNA molecules from the nucleus to the cytoplasm is critical for gene expression. This necessitates the continuous transport of RNA species of different size, shape and function through nuclear pore complexes via export receptors and adaptor proteins. Here, we provide an overview of the major RNA export pathways in humans, highlighting the similarities and differences between each. Its importance is underscored by the growing appreciation that deregulation of RNA export pathways is associated with human diseases like cancer.

Keywords: Disease; Nuclear export; Ribosomal RNA; lncRNA; mRNA; miRNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Active Transport, Cell Nucleus
Animals
Cell Nucleus / metabolism*
Cytoplasm / metabolism*
Humans
Models, Biological
RNA / genetics
RNA / metabolism*
RNA Isoforms / genetics
RNA Isoforms / metabolism*
RNA Transport
RNA-Binding Proteins / genetics
RNA-Binding Proteins / metabolism

Substances

RNA Isoforms
RNA-Binding Proteins
RNA