Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications

Myriam Lawand; Julie Déchanet-Merville; Marie-Caroline Dieu-Nosjean

doi:10.3389/fimmu.2017.00761

Key Features of Gamma-Delta T-Cell Subsets in Human Diseases and Their Immunotherapeutic Implications

Front Immunol. 2017 Jun 30:8:761. doi: 10.3389/fimmu.2017.00761. eCollection 2017.

Authors

Myriam Lawand^{1

2

3}, Julie Déchanet-Merville⁴, Marie-Caroline Dieu-Nosjean^{1

2

3}

Affiliations

¹ Cordeliers Research Center, UMRS 1138, Team "Cancer, Immune Control and Escape", INSERM, Paris, France.
² Cordeliers Research Center, UMRS 1138, University Sorbonne-Paris Cité, University Paris Descartes, Paris, France.
³ Cordeliers Research Center, UMRS 1138, University Pierre and Marie Curie (UPMC), Paris 06, University Paris-Sorbonne, Paris, France.
⁴ ImmunoConcEpT, CNRS UMR 5164, University of Bordeaux, Bordeaux, France.

Abstract

The unique features of gamma-delta (γδ) T cells, related to their antigen recognition capacity, their tissue tropism, and their cytotoxic function, make these cells ideal candidates that could be targeted to induce durable immunity in the context of different pathologies. In this review, we focus on the main characteristics of human γδ T-cell subsets in diseases and the key mechanisms that could be explored to target these cells.

Keywords: NK receptor; antigen presentation; autoimmunity; cancer; cytokine; cytotoxicity; human gamma-delta T cell; infection.

Publication types

Review