Nucleotide Excision Repair and Transcriptional Regulation: TFIIH and Beyond

Annu Rev Biochem. 2016 Jun 2:85:265-90. doi: 10.1146/annurev-biochem-060815-014857.

Abstract

Transcription factor IIH (TFIIH) is a multiprotein complex involved in both transcription and DNA repair, revealing a striking functional link between these two processes. Some of its subunits also belong to complexes involved in other cellular processes, such as chromosome segregation and cell cycle regulation, emphasizing the multitasking capabilities of this factor. This review aims to depict the structure of TFIIH and to dissect the roles of its subunits in different cellular mechanisms. Our understanding of the biochemistry of TFIIH has greatly benefited from studies focused on diseases related to TFIIH mutations. We address the etiology of these disorders and underline the fact that TFIIH can be considered a promising target for therapeutic strategies.

Keywords: DNA repair; TFIIH; cell cycle; human diseases; transcription.

Publication types

  • Review

MeSH terms

  • Cell Cycle / drug effects
  • Cell Cycle / genetics
  • Cell Cycle Proteins / antagonists & inhibitors
  • Cell Cycle Proteins / genetics
  • Cell Cycle Proteins / metabolism
  • Chromosome Segregation
  • DNA / genetics
  • DNA / metabolism
  • DNA Damage
  • DNA Repair / drug effects*
  • Humans
  • Models, Molecular
  • Molecular Targeted Therapy
  • Mutation
  • Phenylenediamines / therapeutic use
  • Protein Subunits / antagonists & inhibitors
  • Protein Subunits / genetics
  • Protein Subunits / metabolism
  • Pyrimidines / therapeutic use
  • Spironolactone / therapeutic use
  • Transcription Factor TFIIH / antagonists & inhibitors
  • Transcription Factor TFIIH / genetics*
  • Transcription Factor TFIIH / metabolism
  • Transcription, Genetic / drug effects*
  • Trichothiodystrophy Syndromes / drug therapy
  • Trichothiodystrophy Syndromes / genetics*
  • Trichothiodystrophy Syndromes / metabolism
  • Trichothiodystrophy Syndromes / pathology
  • Xeroderma Pigmentosum / drug therapy
  • Xeroderma Pigmentosum / genetics*
  • Xeroderma Pigmentosum / metabolism
  • Xeroderma Pigmentosum / pathology

Substances

  • Cell Cycle Proteins
  • Phenylenediamines
  • Protein Subunits
  • Pyrimidines
  • THZ1 compound
  • Transcription Factor TFIIH
  • Spironolactone
  • DNA