Lamin A/C is part of the nuclear lamina, a meshwork of intermediate filaments underlying the inner nuclear membrane. The lamin network is anchoring a complex set of structural and linker proteins and is either directly or through partner proteins also associated or interacting with a number of signaling protein and transcription factors. During mitosis the nuclear lamina is dissociated by well established phosphorylation- dependent mechanisms. A-type lamins are, however, also phosphorylated during interphase. A recent study identified 20 interphase phosphorylation sites on lamin A/C and explored their functions related to lamin dynamics; movements, localization and solubility. Here we discuss these findings in the light of lamin functions in health and disease.
Keywords: EDMD, Emery-Dreifuss muscular dystrophy; GFP, green fluorescent protein; IFs, intermediate filaments; LAP2α, Lamina-associated polypeptide 2 isoform α; intermediate filaments; lamin A/C; laminopathy; lamins; phosphorylation; signaling.