Centriole duplication: when PLK4 meets Ana2/STIL

Minhee Kim; Chii Shyang Fong; Meng-Fu Bryan Tsou

doi:10.1016/j.cub.2014.09.079

Centriole duplication: when PLK4 meets Ana2/STIL

Curr Biol. 2014 Nov 3;24(21):R1046-8. doi: 10.1016/j.cub.2014.09.079. Epub 2014 Nov 3.

Authors

Minhee Kim¹, Chii Shyang Fong², Meng-Fu Bryan Tsou³

Affiliations

¹ Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA.
² Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
³ Cell Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA; Weill Cornell Graduate School of Medical Sciences, Cornell University, New York, NY 10065, USA. Electronic address: tsoum@mskcc.org.

PMID: 25517369
DOI: 10.1016/j.cub.2014.09.079

Abstract

Polo-like kinase 4 is known to drive centriole duplication, but the relevant substrate remains elusive. A new study shows that PLK4 phosphorylates a key centriolar component, Ana2/STIL, to initiate centriole assembly.

Publication types

Comment

MeSH terms

Animals
Cell Cycle Proteins / metabolism*
Centrioles / metabolism*
Drosophila / metabolism*
Drosophila Proteins / metabolism*
Drosophila Proteins / physiology*
Microtubule-Associated Proteins / metabolism*
Protein Serine-Threonine Kinases / physiology*

Substances

Cell Cycle Proteins
Drosophila Proteins
Microtubule-Associated Proteins
Protein Serine-Threonine Kinases

Abstract

Publication types

MeSH terms

Substances

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