Abstract
Coherent splicing networks arise from many discrete splicing decisions regulated in unison. Here, we examine the properties of robust, context-specific splicing networks. We propose that a subset of key splicing regulators, or "master splicing factors," respond to environmental cues to establish and maintain tissue transcriptomes during development.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Alternative Splicing
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Animals
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Feedback
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Gene Expression Regulation, Developmental*
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Homeostasis
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Humans
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Organ Specificity
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RNA Splicing*
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RNA-Binding Proteins / metabolism*
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Transcription Factors / metabolism
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Transcriptome
Substances
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RNA-Binding Proteins
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Transcription Factors